30507-24-5

Upstream product

• 110-89-4 piperidine 
• 77143-47-6 2-[1,2-Dibromo-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-3H-quinazolin-4-one 
• 110-91-8 morpholine 
• 108-98-5 thiophenol 
• 108-95-2 phenol 
• 20850-13-9 3-(4-methoxyphenyl)-allylamine 
• 15310-01-7 benodanil 
• 2385-27-5 N-phenyl-2-nitrobenzamide 
• 610-14-0 2-nitrobenzyl chloride 
• 2385-23-1 2-Methyl-3-phenyl-4(3H)-quinazolinone 
• 123-11-5 4-methoxy-benzaldehyde 
• 552-16-9 ortho-nitrobenzoic acid 
• 54364-31-7 2-(Acetylamino)-N-phenylbenzamide 
• 4424-17-3 2-aminobenzanilide 

Downstream Products

• 77143-47-6 2-[1,2-Dibromo-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-3H-quinazolin-4-one 
• 77143-58-9 2-[2-(4-Methoxy-phenyl)-1,2-bis-phenylsulfanyl-ethyl]-3-phenyl-3H-quinazolin-4-one 
• 77143-57-8 2-[2-(4-Methoxy-phenyl)-1,2-diphenoxy-ethyl]-3-phenyl-3H-quinazolin-4-one 
• 77143-51-2 2-(α-Bromo-β-acetoxy-p-methoxyphenethyl)-3-phenyl-4(3H)-quinazolinone 
• 77143-53-4 2-(α-Bromo-β-ethoxy-p-methoxyphenethyl)-3-phenyl-4(3H)-quinazolinone 
• 77143-52-3 2-(α-Bromo-β-methoxy-p-methoxyphenethyl)-3-phenyl-4(3H)-quinazolinone 
• 77143-54-5 2-[1,2-Diamino-2-(4-methoxy-phenyl)-ethyl]-3-phenyl-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis of 2,3-Disubstituted Quinazolinone Derivatives through Copper Catalyzed C-H Amidation Reactions

The synthesis of quinazolinone derivatives was achieved from 2-iodobenzamide derivatives and various benzylamines, allylamine, and cinnamylamine derivatives through a one-pot copper-catalyzed reaction. In this reaction, the amine component (benzylamine/allylamine/cinnamylamine) is N-arylated with 2-iodobenzamide derivatives through Ullman coupling, followed by an intramolecular C-H amidation in the presence of copper catalyst. Copper-catalyzed tandem-Ullman N-alkylation and intramolecular C-H amidation reaction protocol for the synthesis of 2-phenylquinazolinone and quinazolinone derivatives from N-substituted 2-iodo-benzamides and benzylamines, allyl, and cinnamylamine is achieved.

Synthesis of N -Heteropolycyclic Compounds Including Quinazolinone Skeleton Using Friedel-Crafts Alkylation

A simple method to synthesize N-heteropolycyclic quinazolinones was developed including Knoevenagel condensation of quinazolines and aldehydes and Friedel-Craft alkylation as key steps. Knoevenagel reaction of 2-methyl-3-phenylquinazolin-4(3H)-one proceeded smoothly under a basic condition and subsequent Friedel-Craft alkylation with Bronsted acid gave the N-heteropolycyclic quinazolinones in good yields. Furthermore, these new polycyclic compounds were converted into organic molecules having a long π-conjugation system by treatment of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to utilize them as organic dyes. GRAPHICAL ABSTRACT.

Reactions of 2,3-Disubstituted 4(3H)-Quinazolinones and Related Compounds

Synthesis of the dibromides (IIa-d) of 2-arylidene-3-phenyl-4(3H)-quinazolinones (Ia-d) is described.The reactivity and the effect of substituents on the benzylic halogen atom β- to the -C=N- group of II towards SN1 displacement reaction together with observed E1 elimination reaction are discussed.