1503-87-3

Basic information

• Product Name: 2-cyclohexylacetamide
• Synonyms: cyclohexaneacetamide
• CAS NO: 1503-87-3
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.2108
• Mol File: 1503-87-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 301.3°C at 760 mmHg
• Flash Point: 136°C
• Density: 0.975g/cm³
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.472
• CAS DataBase Reference: 2-cyclohexylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexylacetamide(1503-87-3)
• EPA Substance Registry System: 2-cyclohexylacetamide(1503-87-3)

Safety Data

• Hazardous Substances Data: 1503-87-3(Hazardous Substances Data)

Usage

General Description

2-cyclohexylacetamide is a chemical compound with the molecular formula C8H15NO. It is a colorless or pale yellow liquid with a faint odor, and it is used as a corrosion inhibitor and as an intermediate for the production of pharmaceuticals and agricultural chemicals. 2-cyclohexylacetamide is considered to be relatively low in toxicity and is not considered to be a skin or eye irritant. It is important to handle this chemical with care, as exposure to high concentrations can cause irritation to the respiratory system and skin. Overall, 2-cyclohexylacetamide is a versatile chemical with various industrial applications and should be handled and stored according to standard safety protocols.

Upstream product

• 123-91-1 1,4-dioxane 
• 823-76-7 Cyclohexyl methyl ketone 
• 3675-31-8 2-(cyclohex-2-enyl)acetic acid 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 60-35-5 acetamide 
• 108-93-0 cyclohexanol 
• 100-49-2 cyclohexylmethyl alcohol 
• 2043-61-0 cyclohexanecarbaldehyde 
• 5292-21-7 Cyclohexylacetic acid 
• 23860-35-7 cyclohexylacetic acid chloride 

Downstream Products

• 114906-66-0 5-cyclohexylmethyl-tetrazole 
• 618-42-8 1-piperidin-1-yl-ethanone 
• 4442-85-7 2-cyclohexylethylamine 
• 4998-76-9 cyclohexylamine hydrochloride 
• 108-91-8 cyclohexylamine 
• 766-05-2 cyclohexane carbonitrile 
• 56700-67-5 tert-butyl N-cyclohexylmethylcarbamate 
• 4435-14-7 2-cyclohexylacetonitrile 
• 22155-44-8 cyclohexylmethylcarbamic acid methyl ester 

Relevant articles and documents

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Copper-Catalyzed Amide Radical-Directed Cyanation of Unactivated Csp3-H Bonds

A method for site-selective intermolecular δ/?-Csp3-H cyanation of aliphatic sulfonamides is developed using TsCN as the cyanating reagent, catalyzed by a Cu(I)/phenanthroline complex. The mild, expeditious, and modular protocol allows efficient remote Csp3-H cyanation with good functional group tolerance and high regioselectivity. Mechanistic studies indicate that the reaction might proceed through a Cu(I)-mediated N-F bond cleavage to generate an amidyl radical, 1,5-HAT, and cyano group transfer of the resulting carbon radical with TsCN.

N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities

Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.