239089-26-0

Upstream product

• 122788-52-7 5,5-bis(hydroxymethyl)-2-(4-methoxyphenyl)-1,3-dioxane 
• 123-11-5 4-methoxy-benzaldehyde 
• 77-76-9 2,2-dimethoxy-propane 
• 186090-81-3 2-(hydroxymethyl)-2-(((4-methoxybenzyl)oxy)methyl)propane-1,3-diol 
• 115-77-5 Pentaerythritol 
• 239089-25-9 5,5-Bis(p-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxane 
• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 51335-75-2 2,2-Dimethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid,diethyl ester 
• 770-74-1 2,2-dimethyl-5,5-bis(hydroxymethyl)-1,3-dioxane 

Downstream Products

• 239089-29-3 (1'R)-5-(1'-Hydroxybut-3'-enyl)-5-p-methoxybenzyloxymethyl-2,2-dimethyl-5-(1'-trimethylsilyloxybut-3'-enyl)-1,3-dioxane 
• 239089-33-9 (1'R,3'S)-5-{1',3'-Bistriethylsilyloxy-3'-[furan-2''(5''H)-on-4''-yl]propyl}-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 239089-40-8 (1'R,3'R)-5-{1',3'-Dihydroxy-3'-[furan-2''(5''H)-on-4''-yl]propyl}-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 239089-32-8 (1'R,3'S)-5-{1',3'-Dihydroxy-3'-[furan-2''(5''H)-on-4''-yl]propyl}-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 
• 239089-28-2 5-Formyl-5-p-methoxybenzyloxymethyl-2,2-dimethyl-1,3-dioxane 

Relevant academic research and scientific papers

CATIONIC LIPIDS

The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C1-5 alkyl group, a linear C7-11 alkenyl group, or a linear C11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.

Synthetic studies on azadirachtin: An efficient asymmetric synthesis of the highly functionalized tricyclic decalin part of azadirachtin

The detailed examination of intramolecular Diels-Alder reactions of several structurally related trienes led to construction of the desired tricyclic decalin moiety of azadirachtin with the α-hydroxyl groups at C1 and C3 as well as the oxygenated substituent at C8 in the naturally occurring form in good yields.

Synthetic studies on azadirachtin: Construction of the highly functionalized decalin moiety of azadirachtin

Construction of the left segment of azadirachtin in naturally occurring enantiomer is described. The key reaction is an intramolecular Diels-Alder reaction, which was performed under thermal conditions to afford the highly functionalized decalin compounds selectively.