23936-11-0

Basic information

• Product Name: 3-METHYL-2-PIPERAZINONE
• Synonyms: Piperazinone, 3-Methyl-;3-Methyl-2-ketopiperazine >=97.0% (GC);>=97.0% (GC)
• CAS NO: 23936-11-0
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.14825
• Product Categories: pharmacetical
• Mol File: 23936-11-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 57-59 °C
• Boiling Point: 289.6°C at 760 mmHg
• Flash Point: 148.7°C
• Appearance: /
• Density: 0.992g/cm³
• Vapor Pressure: 0.00217mmHg at 25°C
• Refractive Index: 1.434
• PKA: 15.51±0.40(Predicted)
• CAS DataBase Reference: 3-METHYL-2-PIPERAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-2-PIPERAZINONE(23936-11-0)
• EPA Substance Registry System: 3-METHYL-2-PIPERAZINONE(23936-11-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 23936-11-0(Hazardous Substances Data)

Usage

Chemical Properties

beige powder

InChI:InChI=1/C5H10N2O/c1-4-5(8)7-3-2-6-4/h4,6H,2-3H2,1H3,(H,7,8)

Upstream product

• 75-07-0 acetaldehyde 
• 107-15-3 ethylenediamine 
• 78-97-7 2-hydroxy-propionitrile 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 5445-17-0 Methyl 2-bromopropionate 
• 19838-07-4 3-methyl-2-hydroxypyrazine 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 29906-47-6 1-benzyl-2-methylpiperazin-3-one 
• 25057-77-6 1,2-dimethylpiperazine 
• 90152-49-1 3-methylpiperazine-1-carboxylic acid ethyl ester 
• 114649-94-4 3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester 
• 114649-92-2 3-Methyl-piperazine-1-carboxylic acid dimethylamide 
• 114649-88-6 1,2-dimethyl-4-(N,N-dimethylcarbamoyl) piperazine 
• 114649-86-4 1-(N,N-dimethylcarbamoyl)-2,4-dimethylpiperazine 
• 114649-85-3 1-carbethoxy-2,4-dimethylpiperazine 
• 109055-55-2 1-benzyl-2,4-dimethylpiperazine 
• 114649-87-5 Cyclohexyl-(2,4-dimethyl-piperazin-1-yl)-methanone 
• 114649-90-0 4-Benzyl-3-methyl-piperazine-1-carboxylic acid dimethylamide 
• 114649-91-1 4-Benzyl-3-methyl-piperazine-1-carboxylic acid diethylamide 
• 114649-89-7 (4-Benzyl-3-methyl-piperazin-1-yl)-cyclohexyl-methanone 
• 92699-31-5 4-benzyl-3-methyl-piperazine-1-carboxylic acid ethyl ester 

Relevant articles and documents

Selective NK-3 receptor antagonist, preparation and application thereof

The invention provides a selective NK-3 receptor antagonist, preparation and application thereof, particularly a compound represented by the following formula (I). The compound of the invention has unexpected activity to modulate cytokines and/or interferon, and is useful in the treatment of CNS and peripheral diseases or disorders.

Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation

The asymmetric palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2- ones allows the synthesis of a variety of highly enantioenriched tertiary piperazine-2-ones. Deprotection and reduction affords the corresponding tertiary piperazines, which can be employed for the synthesis of medicinally important analogues. The introduction of these chiral tertiary piperazines resulted in imatinib analogues which exhibited comparable antiproliferative activity to that of their corresponding imatinib counterparts.

Studies in Potential Filaricides: Part 20 - Synthesis of 1,4-Disubstituted Piperazines as Diethylcarbamazine Analogs

A series of substituted 2,4-dimethylpiperazines (10-15), 1-benzyl-2-methylpiperazines (16-19), 1-substituted 3-methylpiperazines (20-25,27) and 1,4-disubstituted piperazines (28-34) have been synthesized starting from 1-benzyl-2-methylpiperazine (9) and 1