23942-99-6

Basic information

• Product Name: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol
• Synonyms: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol;alpha-narcotinediol
• CAS NO: 23942-99-6
• Molecular Formula: C₂₂H₂₇NO₇
• Molecular Weight: 417.45228
• EINECS: 245-946-7
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 23942-99-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-132 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
• Boiling Point: 570.3°Cat760mmHg
• Flash Point: 298.7°C
• Appearance: /
• Density: 1.3g/cm³
• PKA: 13.25±0.20(Predicted)
• CAS DataBase Reference: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol(CAS DataBase Reference)
• NIST Chemistry Reference: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol(23942-99-6)
• EPA Substance Registry System: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol(23942-99-6)

Safety Data

• Hazardous Substances Data: 23942-99-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

(-)-α-Narcotinediol is a Narcotine derivative, a noscapinoid class of microtubule binding compounds that alter microtubule dynamics without affecting tubulin polymer mass. Noscapinoids show great promise as chemotherapeutic agents for the treatment of human cancers. Unlike Narcotine, (-)-α-Narcotinediol deos not inhibit small-intestinal transport in rats.

Upstream product

• 106982-93-8 (+)-papaveroxinoline 
• 128-62-1 noscapine 
• 106982-95-0 narcotinediol diacetate 
• 71-43-2 benzene 

Downstream Products

• 42011-37-0 (13aR)-9,10,14-trimethoxy-7ξ-methyl-13c-(toluene-4-sulfonyloxy)-(13ar)-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; chloride 
• 106982-93-8 (+)-papaveroxinoline 
• 136617-42-0 isopapaveroxinoline 
• 136617-41-9 O-acetylnarcotinediol 7'-silyl ether 
• 35306-96-8 9,10-dimethoxy-13-methyl-5,13-dihydro-6H,8H-benzo[g][1,3]dioxolo[4',5':7,8]chromeno[3,4,5-ija]quinolizine 
• 87633-33-8 2-(3,4-Dimethoxyphenyl)-3-dimethylamino-6,7-methylendioxy-4-vinyl-dihydrobenzofuran 
• 87633-32-7 2-(3,4-Dimethoxyphenyl)-2a,3,4,5-tetrahydro-3-methyl-7,8-methylendioxy-2H-furo<2,3,4-i,k>isochinolin 
• 10421-76-8 noscapine 
• 136617-40-8 narcotinediol 7'-silyl ether 
• 106982-95-0 narcotinediol diacetate 
• 65620-68-0 (S)-5-(3,4-dimethoxy-2-methyl-benzyl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 42011-37-0 9,10,14-trimethoxy-7ξ-methyl-13c-(toluene-4-sulfonyloxy)-(13ar)-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; chloride 
• 82-54-2 4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-ol 

Relevant articles and documents

Conversion of hydrastine into berberine, and an instance of the asymmetrical quaternization of a tertiary base.

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The influence of the alkaloid narcotine and its dioles on the histamine level of the tissue

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