23973-51-5

Usage

Uses

Used in Chemical Synthesis:
Allylthioacetate is used as a chemical intermediate for the synthesis of various organic compounds. Its reactivity and the presence of the allyl group make it a valuable building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Laboratory Research:
In the field of organic chemistry, Allylthioacetate is used as a research compound to study the reactions and properties of organosulfur compounds. It aids in understanding the mechanisms of various chemical transformations and can be employed in the development of new synthetic methods and strategies.
Used in Industrial Applications:
Allylthioacetate is utilized in the production of industrial chemicals, where its unique chemical properties contribute to the formation of desired products. Its role in these processes is crucial for the synthesis of certain materials that have specific applications in various industries.
Used in Safety Training:
Due to its potentially hazardous nature, Allylthioacetate is also used in safety training programs to educate chemists and laboratory technicians on the importance of proper handling, storage, and disposal of chemicals. This helps in promoting a culture of safety and awareness in the chemical industry.

Upstream product

• 34832-35-4 sodium thioacetate 
• 107-05-1 3-chloroprop-1-ene 
• 106-95-6 allyl bromide 
• 507-09-5 tiolacetic acid 
• 6728-21-8 allyl mesylate 
• 107-18-6 allyl alcohol 
• 10387-40-3 potassium thioacetate 
• 870-23-5 prop-2-ene-1-thiol 
• 108-24-7 acetic anhydride 
• 16621-54-8 thioacetic acid S-(2,3-dichloro-propyl ester) 

Downstream Products

• 870-23-5 prop-2-ene-1-thiol 
• 2179-57-9 diallyl disulphide 
• 1448510-33-5 S-(1,7-dioxo-1,7-diphenylheptan)-4-yl O-ethyl carbonodithioate 
• 14418-84-9 allylsulfonyl chloride 

Relevant academic research and scientific papers

Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides

We synthesized a series of small symmetrical unsaturated disulfides by a multi-step reaction starting from organic alcohols, and we performed a preliminary test to evaluate the effect of these compounds on the viability of A549 lung cancer cells. The garlic-derived natural compound diallyl disulfide, known for its anticancer activity, was used as the lead compound in this study. We synthesized five DADS analogues having different carbon chain lengths and different positions of the double bonds. Two analogues exhibited a promising antitumor activity in vitro, and the allylic double bond did not seem to be the main driving force.

Efficient synthesis of organic thioacetates in water

Thioacetates as precursors of thiols are interesting starting points for synthesizing other organosulfur compounds. Herein, we propose a simple, efficient and fast method to obtain organic thioacetates using water as a solvent. Taking into account the great attention that has been paid toward environmentally friendly synthetic procedures in the past decades, we prove the role and the strength of the thioacetate anion as a nucleophile for nucleophilic displacement reactions in an aqueous medium. The reactions were carried out under pH control, to prevent the decomposition of the mesylate starting materials, using potassium carbonate as a safe and mild base. A simple work up allows products to be obtained with excellent yield and acceptable purity.

Method of manufacturing compds. Allylnaphthol

PROBLEM TO BE SOLVED: To provide a production method of an allyl compound of carrying out the dehydration allylation of a substrate having S, C or N which is a nucleophilic atom, especially S under the presence of a catalyst system consisting of a catalyst precursor having a specific structure and a specific ligand. SOLUTION: The production method of allyl compounds comprises as follow. A catalyst precursor chosen from Formula (1) and Formula (2) and a ligand are mixed, or a catalyst precursor, an allyl alcohol, and a ligand are mixed, then allyl alcohols and a substrate are blended and made to react. The ligand is quinaldic acid or picolinic acid, and the substrate is thiols, thiocarboxylic acids or the like. [Ru(C5H5)(CH3CN)3]PF6(1). [Ru[C5(CH3)5](CH3CN)3]PF6(2). COPYRIGHT: (C)2012,JPOandINPIT

Allyl sulphides in olefin metathesis: Catalyst considerations and traceless promotion of ring-closing metathesis

Allyl sulphides are reactive substrates in ruthenium-catalysed olefin metathesis reactions, provided each substrate is matched with a suitable catalyst. A profile of catalyst activity is described, along with the first demonstration of allyl sulphides as traceless promoters in relayed ring-closing metathesis reactions. This journal is

OLEFIN METATHESIS REACTIONS OF AMINO ACIDS, PEPTIDES AND PROTEINS CONTAINING ALLYL SULFIDE GROUPS

A method for the modification of an amino acid, protein or peptide is disclosed. The method comprises reacting a carbon-carbon double bond-containing compound with an amino acid, a protein or a peptide containing an allyl sulfide group in the presence of a catalyst which promotes olefin metathesis, to form a modified amino acid, protein or peptide. Preferred carbon-carbon double bond-containing compounds include carbohydrates.

Highly efficient catalytic dehydrative S-allylation of thiols and thioic S-acids

A SH-selective allylation method using [CpRu(2-quinolinecarboxylato) (η3-C3H5)]PF6 has been realized in various solvents including aqueous media to give allyl sulfides and allyl S-thioates, demonstrating the potential applicability to lipopeptide chemistry.

Allyl sulfides are privileged substrates in aqueous cross-metathesis: Application to site-selective protein modification

Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second generation catalyst 1. The high reactivity of allyl sulfides in cross-metathesis was exploited in the first examples of cross-metathesis on a protein surface. S-Allylcysteine was incorporated chemically into the protein, providing the requisite allyl sulfide handle. Preliminary efforts to genetically incorporate S-allylcysteine into proteins are also reported. Copyright

Practical preparation of esters and thioacetates from alkyl halides and carboxylates or thioacetate catalyzed by PEG400 without solvent

Carboxylic esters and thioacetates were conveniently prepared in good to excellent yields under mild conditions by the reaction of alkyl halides with sodium carboxylates or sodium thioacetate catalyzed by PEG400 in the absence of solvents. Copyright Taylor & Francis Group, LLC.

A facile and practical method for the preparation of thioacetates from alkyl halides and sodium thioacetate catalysed by PEG400

Thioacetates are conveniently prepared in high yields under mild conditions by the reaction of alkyl halides and sodium thioacetate, prepared in situ from thioacetic acid and sodium carbonate, catalysed by PEG400 at room temperature.

A general and mild synthesis of thioesters and thiols from halides

The conversion of a wide variety of halides to thioesters by reaction with potassium thiocetate under mild conditions is described, and the generality of the method is demonstrated.