24167-51-9

Usage

Uses

Used in Organic Synthesis:
3-bromo-N,N-dimethylbenzamide is utilized as a reagent in the production of various organic compounds. Its unique structure and reactivity make it a valuable component in the synthesis of a range of organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-bromo-N,N-dimethylbenzamide is employed as a reagent for the development of new pharmaceutical compounds. Its potential pharmacological properties are being explored, making it a promising candidate for the creation of novel therapeutic agents.
Used in Medicinal Chemistry:
3-bromo-N,N-dimethylbenzamide is also used in the field of medicinal chemistry, where it is investigated for its potential applications in drug discovery and design. Its unique chemical properties and reactivity contribute to the advancement of medicinal chemistry research.

InChI:InChI=1/C9H10BrNO/c1-11(2)9(12)7-4-3-5-8(10)6-7/h3-6H,1-2H3

Upstream product

• 1711-09-7 3-bromobenzoyl chloride 
• 124-40-3 dimethyl amine 
• 127-19-5 N,N-dimethyl acetamide 
• 585-76-2 m-bromobenzoic acid 

Downstream Products

• 153435-27-9 3-N,N-dimethylcarbamoylphenyltri-n-butylstannane 
• 1040751-80-1 C₁₇H₁₈N₄O₂ 
• 1240286-33-2 {4-chloro-2-[(3-dimethylaminocarbonylphenyl)ethynyl]phenoxy}acetic acid 
• 1447932-29-7 N,N-dimethyl-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-3-carboxamide 
• 3132-99-8 m-bromobenzoic aldehyde 
• 832114-07-5 N,N-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 1613045-50-3 (Z)-N-(1-(3-bromophenyl)-1-(dimethylamino)-3-oxo-3-phenylprop-1-en-2-yl)-4-methylbenzenesulfonamide 
• 1613045-51-4 C₂₄H₂₃BrN₂O₃S 
• 952527-19-4 2-(3-(dimethylcarbamoyl)phenyl)-4-methyl-penta-2,3-dienoic acid methyl ester 
• 952527-68-3 carbonic acid 3-(3-(dimethylcarbamoyl)phenyl)-1,1-dimethyl-prop-2-ynyl ester methyl ester 
• 952527-67-2 3-(3-hydroxy-3-methyl-but-1-ynyl)-N,N-dimethylbenzamide 
• 4885-18-1 3-bromo-N,N-dimethylbenzylamine 

Relevant academic research and scientific papers

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and, potentially, therapeutics. Although several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Herein, we report the structure-based design of a new class of alanine-containing 3-arylindoles as potent and selective PRMT4 inhibitors, and describe key structure–activity relationships for this class of compounds.

LXR MODULATORS

The present invention provides compounds of Formula I and Formula II: or pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXRs), and compositions comprising any of such novel compounds and methods of use thereof. These compounds are useful as medicaments for treatment and/or prophylaxis for diseases or conditions related to activity of LXRs.

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

A novel method for the conversion of carboxylic acids to N,N-dimethylamides using N,N-dimethylacetamide as a dimethylamine source

A simple, cost effective and environmentally benign method is reported for the preparation of N,N-dimethylamides from carboxylic acids. The versatility of the method is determined by synthesising a large number of N,N-dimethylamide derivatives. Carboxylic acids are heated at 160-165°C in N,N-dimethylacetamide solvent in the presence of1,1'-carbonyldiimidazole to afford the corresponding N,N-dimethylamides in good to excellent yields.

PHENOXY ACETIC ACID DERIVATIVES

The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.

Transition Metal Phosphine Complexes Possessing Phase Transfer Function. Preparation and Reactivities of Palladium Complexes Containing Quaternary Ammonium Groups

A new type of phosphine ligands (L) bearing quaternary ammonium as a functional group was synthesized.Their palladium complexes, PdBr2L2, readily underwent halogen exchange with powdered NaI under two-phase conditions, and efficiently catalyzed the fluorocarbonylation of phenyl bromide with powdered KF at atmospheric pressure of CO.