832114-07-5

Basic information

• Product Name: 3-(N,N-DIMETHYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER
• Synonyms: N,N-DIMETHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZAMIDE;3-(N,N-DIMETHYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER;3-(Dimethylcarbamoyl)benzeneboronic acid, pinacol ester;N,N-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, 2-[3-(Dimethylcarbamoyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 832114-07-5
• Molecular Formula: C₁₅H₂₂BNO₃
• Molecular Weight: 275.15
• Product Categories: blocks;BoronicAcids;Carboxes
• Mol File: 832114-07-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 416.1°C at 760 mmHg
• Flash Point: 205.4°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 3.93E-07mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 3-(N,N-DIMETHYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N,N-DIMETHYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(832114-07-5)
• EPA Substance Registry System: 3-(N,N-DIMETHYLAMINOCARBONYL)PHENYLBORONIC ACID, PINACOL ESTER(832114-07-5)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 832114-07-5(Hazardous Substances Data)

Usage

Uses

3-(N,N-Dimethylaminocarbonyl)phenylboronic acid pinacol ester

InChI:InChI=1/C15H22BNO3/c1-14(2)15(3,4)20-16(19-14)12-9-7-8-11(10-12)13(18)17(5)6/h7-10H,1-6H3

Upstream product

• 611-74-5 N,N-dimethylbenzamide 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 
• 24167-51-9 3-bromo-N,N-dimethylbenzamide 
• 1711-09-7 3-bromobenzoyl chloride 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 

Downstream Products

• 1446086-46-9 cyclohexylcarbamic acid 6-benzyloxy-3′-dimethylcarbamoylbiphenyl-3-yl ester 

Relevant articles and documents

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and, potentially, therapeutics. Although several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Herein, we report the structure-based design of a new class of alanine-containing 3-arylindoles as potent and selective PRMT4 inhibitors, and describe key structure–activity relationships for this class of compounds.

Amide Effects in C?H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides

A new concept for the meta-selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand has been employed and engages in an O???K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C?H activation/borylation.

BIPYRIDYL COMPOUND

There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound. There is provided a bipyridyl compound represented by a general f