4885-18-1

Basic information

• Product Name: (3-BROMOBENZYL)DIMETHYLAMINE
• Synonyms: 3-(N,N-DIMETHYLAMINOMETHYL)BROMOBENZENE;(3-BROMOBENZYL)DIMETHYLAMINE;(3-BROMOBENZYL)DIMETHYLBENZYLAMINE;1-(3-BROMOPHENYL)-N,N-DIMETHYLMETHANAMINE;(3-Bromophenyl)-N,N-dimethylmethylamine;3-Bromo-N,N-dimethylbenzylamine;BenzeneMethanaMine, 3-broMo-N,N-diMethyl-
• CAS NO: 4885-18-1
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.1
• Product Categories: Amino;Aryl;Organohalides;alkyl bromide
• Mol File: 4885-18-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 227 °C at 760 mmHg
• Flash Point: 91.1 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 0.0792mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.71±0.28(Predicted)
• CAS DataBase Reference: (3-BROMOBENZYL)DIMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BROMOBENZYL)DIMETHYLAMINE(4885-18-1)
• EPA Substance Registry System: (3-BROMOBENZYL)DIMETHYLAMINE(4885-18-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4885-18-1(Hazardous Substances Data)

Usage

General Description

(3-Bromobenzyl)dimethylamine is a chemical compound that belongs to the class of aromatic amines. It is an organic compound with the molecular formula C9H12BrN and a molar mass of 215.10 g/mol. This chemical is derived from benzylamine, in which one of the hydrogen atoms on the benzene ring is replaced by a bromine atom, and two methyl groups are attached to the amine nitrogen. It is widely used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. Additionally, it is utilized as a reagent in organic synthesis to introduce the (3-bromobenzyl)dimethylamino group into different molecules. As a tertiary amine, it exhibits basic properties and can be employed in the production of quaternary ammonium salts and pharmaceuticals.

InChI:InChI=1/C9H12BrN/c1-11(2)7-8-4-3-5-9(10)6-8/h3-6H,7H2,1-2H3

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 100-97-0 hexamethylenetetramine 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 
• 823-78-9 meta-bromobenzyl bromide 
• 585-76-2 m-bromobenzoic acid 
• 1711-09-7 3-bromobenzoyl chloride 
• 24167-51-9 3-bromo-N,N-dimethylbenzamide 
• 50339-64-5 (isobutoxymethyl)dimethylamine 
• 108-36-1 1,3-dibromobenzene 
• 71323-99-4 (3-bromo-benzyl)-trimethyl-ammonium; bromide 

Downstream Products

• 126631-39-8 α-(6,11-dihydrodibenzothiepin-11-yl)-3-(dimethylaminomethyl)benzyl alcohol 
• 869846-80-0 (E)-3-(3-dimethylaminomethyl-phenyl)-acrylic acid ethyl ester 
• 1247001-40-6 (E)-N,N-dimethyl-1-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenyl)methanamine 
• 1134206-52-2 AcSCH₂P(C₆H₄-m-CH₂NMe₂)2 
• 1134206-49-7 BH₃*AcSCH₂P(C₆H₄-m-CH₂NMe₂)2 
• 1134206-46-4 BH₃*HP(C₆H₄-m-CH₂NMe₂)2 
• 1401317-94-9 3-(dimethylsilyl)benzyl 3-iodobenzoate 
• 1401317-92-7 3-(dimethylsilyl)benzyl 4-chlorobenzoate 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1134206-43-1 HP(O)(C₆H₄-m-CH₂NMe₂)2 

Relevant articles and documents

A Novel Route to Synthesize N,N-Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen?

Developing simple and green routes to access valuable chemicals is of significance. Herein, we present a green and novel route to synthesize N,N-dimethyl arylmethylamines (DAMAs) from hexamethylenetetramine (HMTA) and aryl aldehydes in the presence of hydrogen, and a series of DAMAs can be obtained in good yields. This approach opens the precedent for HMTA as N,N-dimethylamine source to synthesize chemicals with N,N-dimethylamine group, which has promising applications for N-containing chemicals synthesis.

Simple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis

Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by commercially available AsPh3 as the ligand and a unique "acetate cocktail". Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work.

7-(Aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: Addition of water solubilizing groups

New 4-phenylamino-3-quinolinecarbonitriles with a 7-ethynyl group substituted by a pyridine, phenyl or thiophene ring containing basic water solubilizing groups were prepared and evaluated as Src kinase inhibitors. Of these new analogs, potent activity wa