4885-18-1

Usage

Uses

Used in Pharmaceutical Industry:
(3-BROMOBENZYL)DIMETHYLAMINE is used as a building block for the synthesis of various biologically active compounds, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
(3-BROMOBENZYL)DIMETHYLAMINE is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its ability to form stable and effective molecules for crop protection.
Used in Organic Synthesis:
(3-BROMOBENZYL)DIMETHYLAMINE is used as a reagent to introduce the (3-bromobenzyl)dimethylamino group into different molecules, enhancing their properties and reactivity in various chemical reactions.
Used in Production of Quaternary Ammonium Salts:
As a tertiary amine, (3-BROMOBENZYL)DIMETHYLAMINE can be employed in the production of quaternary ammonium salts, which have applications in various industries, including disinfection, fabric softening, and cationic surfactants.
Used in Pharmaceutical Development:
(3-BROMOBENZYL)DIMETHYLAMINE is used as a key intermediate in the synthesis of pharmaceuticals, enabling the creation of new drug candidates with improved efficacy and selectivity for targeted treatments.

InChI:InChI=1/C9H12BrN/c1-11(2)7-8-4-3-5-9(10)6-8/h3-6H,7H2,1-2H3

Upstream product

• 100-97-0 hexamethylenetetramine 
• 823-78-9 meta-bromobenzyl bromide 
• 124-40-3 dimethyl amine 
• 3132-99-8 m-bromobenzoic aldehyde 
• 506-59-2 N,N-dimethylammonium chloride 
• 585-76-2 m-bromobenzoic acid 
• 1711-09-7 3-bromobenzoyl chloride 
• 24167-51-9 3-bromo-N,N-dimethylbenzamide 
• 71323-99-4 (3-bromo-benzyl)-trimethyl-ammonium; bromide 
• 50339-64-5 (isobutoxymethyl)dimethylamine 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 153523-19-4 (3-Diphenylphosphanyl-benzyl)-dimethyl-amine 
• 869846-80-0 (E)-3-(3-dimethylaminomethyl-phenyl)-acrylic acid ethyl ester 
• 69383-72-8 3-(N,N-Dimethylaminomethyl)benzenemethanol 
• 1134206-43-1 HP(O)(C₆H₄-m-CH₂NMe₂)2 
• 1247001-40-6 (E)-N,N-dimethyl-1-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenyl)methanamine 
• 1134206-52-2 AcSCH₂P(C₆H₄-m-CH₂NMe₂)2 
• 1134206-49-7 BH₃*AcSCH₂P(C₆H₄-m-CH₂NMe₂)2 
• 1134206-46-4 BH₃*HP(C₆H₄-m-CH₂NMe₂)2 
• 1401317-94-9 3-(dimethylsilyl)benzyl 3-iodobenzoate 
• 1401317-92-7 3-(dimethylsilyl)benzyl 4-chlorobenzoate 
• 3132-99-8 m-bromobenzoic aldehyde 

Relevant academic research and scientific papers

A Novel Route to Synthesize N,N-Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen?

Developing simple and green routes to access valuable chemicals is of significance. Herein, we present a green and novel route to synthesize N,N-dimethyl arylmethylamines (DAMAs) from hexamethylenetetramine (HMTA) and aryl aldehydes in the presence of hydrogen, and a series of DAMAs can be obtained in good yields. This approach opens the precedent for HMTA as N,N-dimethylamine source to synthesize chemicals with N,N-dimethylamine group, which has promising applications for N-containing chemicals synthesis.

Electrochemical Dehydrogenative Imidation of N-Methyl-Substituted Benzylamines with Phthalimides for the Direct Synthesis of Phthalimide-Protected gem-Diamines

A general and green electrochemical dehydrogenative method for the imidation of N-methyl benzylamines with phthalimides with excellent regioselectivities is reported for the first time. This operationally simple method offers a valuable tool to obtain str

Simple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis

Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by commercially available AsPh3 as the ligand and a unique "acetate cocktail". Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work.

Dual antitumor and antiangiogenic activity of organoplatinum(II) complexes

A library of over 20 cycloplatinated compounds of the type [Pt(dmba-R)LCl] (dmba-R = C,N-dimethylbenzylamine-like ligand; R being MeO, Me, H, Br, F, CF3, and NO2 substituents in the R5 or R4 position of the phenyl ring; L = DMSO and P(C6H4CF3-p)3) has been prepared. All compounds are active in both human ovarian carcinoma A2780 cells and cisplatin-resistant A2780cisR cells, with most of the DMSO platinum complexes exhibiting IC50 values in the submicromolar range in the A2780 cell line. Interestingly, DMSO platinum complexes show low cytotoxicity in the nontumorigenic kidney cell line BGM and therefore high selectivity factors SF. In addition, some of the DMSO platinum complexes effectively inhibit angiogenesis in the human umbilical vein endothelial cell line EA.hy926. These are the first platinum(II) complexes reported to inhibit angiogenesis at a close concentration to their IC50 in A2780 cells, turning them into dual cytotoxic and antiangiogenic compounds.

7-(Aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: Addition of water solubilizing groups

New 4-phenylamino-3-quinolinecarbonitriles with a 7-ethynyl group substituted by a pyridine, phenyl or thiophene ring containing basic water solubilizing groups were prepared and evaluated as Src kinase inhibitors. Of these new analogs, potent activity wa

Transition Metal Phosphine Complexes Possessing Phase Transfer Function. Preparation and Reactivities of Palladium Complexes Containing Quaternary Ammonium Groups

A new type of phosphine ligands (L) bearing quaternary ammonium as a functional group was synthesized.Their palladium complexes, PdBr2L2, readily underwent halogen exchange with powdered NaI under two-phase conditions, and efficiently catalyzed the fluorocarbonylation of phenyl bromide with powdered KF at atmospheric pressure of CO.

Potential Antidepressants. Synthesis of 6,11-Dihydrodibenzothiepin-11-yl 4-(Dimethylaminomethyl)phenyl Ketone and of Some Related Compounds

Reactions of dibenzothiepin-11(6H)-one (4) with 2-, 3- and 4-(dimethylaminomethyl)phenylmagnesium bromide afforded the tertiary alcohols 5a,b,c.The aldehydes 7 and 8 gave similarly the secondary alcohols 9a,b,c and 10c.Numerous attempts to prepare the corresponding ketones, especially by oxidation of 9a,b,c and 10c were unsuccessful.Only the oxidation of 9c with tetrabutylammonium chromate in chloroform afforded the desired ketone 16.Its formation was accompanied by an important side reaction consisting in a cleavage of the "retro-ene-reaction" type leading to compound 11 and the aldehyde 13c which reacted with the chloroform present to give the alcohol 17.Compounds 5a,b,c, 9a,b,c and 16 were tested as potential antidepressants but with the exception of some effects in the test of potentiation of yohimbine toxicity in mice, they proved inactive in this line.

PHENYL ALKYLAMINOPYRIMIDONES

The compounds are phenyl alkylaminopyrimidones which are histamine H. sub.2-antagonists. A specific compound of the present invention is 2-[2-[3-(dimethylaminomethyl)benzylthio]ethylamino]-5-(6-methyl-3-pyridylme thyl)-4-pyrimidone.