24290-58-2

Usage

Uses

Used in Pharmaceutical Industry:
(3-phenylaziridine-1,2-diyl)bis(phenylmethanone) serves as a key intermediate in the synthesis of pharmaceutical compounds, leveraging its reactivity and structural diversity to facilitate the creation of new drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
In agrochemicals, (3-phenylaziridine-1,2-diyl)bis(phenylmethanone) is utilized as a chemical intermediate for the development of pesticides and other agricultural chemicals, contributing to more effective and targeted pest control solutions.
Used in Materials Science:
(3-phenylaziridine-1,2-diyl)bis(phenylmethanone) is employed in materials science for the synthesis of advanced materials with unique properties, such as high reactivity or stability, which can be applied in various industrial and technological applications.

Upstream product

• 65309-87-7 (2R,3S)-phenyl-(3-phenylaziridin-2-yl)methanone 
• 98-88-4 benzoyl chloride 
• 7570-84-5 trans-2-phenyl-3-benzoylaziridine 
• 65-85-0 benzoic acid 
• 538-75-0 dicyclohexyl-carbodiimide 
• 614-47-1 1,3-diphenyl-propen-3-one 

Downstream Products

• 614-47-1 1,3-diphenyl-propen-3-one 
• 24294-71-1 1,4-diphenyl-4-benzoyloxy-2-azabutadiene 
• 24806-70-0 N-[(Z)-1-oxo-1,3-diphenylprop-2-en-2-yl]benzamide 
• 24807-19-0 (2,4-diphenyloxazol-5-yl)(phenyl)methanone 
• 24806-73-3 ((anti)-2,4-diphenyl-4,5-dihydrooxazol-5-yl)(phenyl)methanone 
• 74213-57-3 (-)-2,4-diphenyl-5-benzoyloxy-2-oxazoline 
• 96392-53-9 N-(2-hydroxy-1-phenylethyl)benzamide 
• 24806-73-3 (-)-trans-2,4-diphenyl-5-benzoyl-2-oxazoline 

Relevant academic research and scientific papers

Regio-controlled and stereo-controlled ring expansion of N-substituted-2 benzoylaziridines using Fe(NO3)3

Several N-acyl-2-benzoylaziridines were previously prepared conveniently and used in the preparation of 5-benzoyl-2,4-diaryl oxazolines in the presence of NaI. In this work, synthesis of some trans-4-benzoyl- 2,5-diaryl oxazolines by a regio-controlled an

K5[PW11ZnO39].23H2O-catalyzed acylation/ring expansion of ketoaziridines in a single pot: A new regio- and stereo-selective route for the synthesis of oxazolines

A new and one-pot synthesis of oxazolines has been accomplished by K5[PW11ZnO39].23H2O - catalyst acylation followed by C-N ring opening/C-O bond formation in NH ketoaziridines. This regio- and stereo-selective reaction presumably proceeds via a domino sequence resulting in the in situ generation of acyl aziridine which undergoes a ring expansion reaction via an initial C-N rupture of aziridine ring followed by ring closure to the oxazolines. The methodology provided novel one-pot procedure for the synthesis of trans-2,5-diaryl-4-aroyloxazolines.

Fe(NO3)3 as an efficient catalyst for regio- and stereo-controlled ring expansion of 1,2-diaroyl-3-arylaziridines

Several 1,2-diaroyl-3-arylaziridines were previously prepared conveniently and used in the preparation of 5-benzoyl-2,4-diaryl oxazolines in the presence of NaI. In this work, synthesis of some trans-4-benzoyl-2,5-diaryl oxazolines by a regio- and stereo-controlled reaction in the presence of Iron (III) nitrate at room temperature is reported. A plausible mechanism has been proposed for ring expansion of N-acyl aziridines to oxazolines.

Regio- and stereo-controlled isomerization of 1,2-diaroyl-3-aryl aziridines to the corresponding N-((Z)-1-oxo-1,3-diphenylprop-2-en-2-yl) benzamide

Regio- and stereo-controlled isomerization of 1,2-diaroyl-3-aryl aziridines to the corresponding N-((Z)-1-oxo-1,3-diphenylprop-2-en-2-yl) benzamide in the presence of diethyl thiourea in room temperature is described. A plausible mechanism has been proposed. The structures of the products were confirmed by X-ray analysis.

An efficient synthesis of 5-benzoyloxazolines by regio- and stereo-controlled reaction of N-substituted 2-benzoylaziridines under microwave irradiation

(Chemical Equation Presented) Several N-acyl-2-benzoylaziridines were prepared conveniently in good to high yields (71-93%) and used in the preparation of 5-benzoyloxazolines (76-91%) by a regio- and stereo-controlled reaction in the presence of NaI as an

ONE STEP SYNTHESIS OF AZIRIDINES BY THE MICHAEL TYPE ADDITION OF FREE SULFIMIDES

The Michael type additions of diphenyl N-unsubstituted sulfimide (free sulfimide) to various electrophilic olefins were carried out.The reaction with cis- and trans-dibenzoylethylene, dimethylfumarate, dimethylmaleate, benzalacetophenone and benzalacetone gave mainly the corresponding trans-2-acylaziridines and trans-enaminoketones.However, phenyl vinyl sulfone or acrylonitrile afforded not the corresponding aziridine but diphenyl-N-2-cyano or N-2-phenylsulfonylethylsulfimide, a simple Michael adduct.When optically active (+)-(R)-o-methoxyphenylphenyl free sulfimide was treated with such an α,β-unsaturated carbonyl compound as benzalacetophenone, an optically active 2-acylaziridine, i.e., (-)-trans-2-benzoyl-3-phenylaziridine was obtained in ca 30percent optical purity and its absolute configuration was assigned as (2R,3S) upon chemical transformation to the configurationally known 2-phenyl-2-benzoylamino-1-ethanol or by comparing its CD spectrum with that of (1R,2R)-1-phenyl-2-benzoyl-cyclopropane.Meanwhile, (-)-(S)-o-methoxyphenylphenyl free sulfimide was found to react with benzalacetophenone to afford (+)-trans-2-benzoyl-3-phenylaziridine of 25percent optical purity.Effects of solvent and temperature on both the distribution of the products ratio and the optical yield were examined.