2432-34-0

Basic information

• Product Name: Thioacetic acid S-octyl ester
• Synonyms: Thioacetic acid S-octyl ester
• CAS NO: 2432-34-0
• Molecular Formula: C₁₀H₂₀OS
• Molecular Weight: 188.33
• Mol File: 2432-34-0.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thioacetic acid S-octyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Thioacetic acid S-octyl ester(2432-34-0)
• EPA Substance Registry System: Thioacetic acid S-octyl ester(2432-34-0)

Safety Data

• Hazardous Substances Data: 2432-34-0(Hazardous Substances Data)

Upstream product

• 17642-74-9 2-methyl-1,3-oxathiolane 
• 592-41-6 1-hexene 
• 74-85-1 ethene 
• 29632-72-2 (R)-thioacetate 
• 103514-65-4 C₁₄H₃₅N₃PS⁽¹⁺⁾ 
• 108-24-7 acetic anhydride 
• 222735-64-0 octyl 2-(trimethylsilyl)ethyl sulfide 
• 111-85-3 n-chlorooctane 
• 111-83-1 1-bromo-octane 
• 3386-35-4 1-octyl p-toluenesulfonate 
• 111-88-6 Octanethiol 
• 243990-72-9 acetic acid 1-(2,5-dichloro-phenyl)-2,2-bis-methylsulfanyl-vinyl ester 
• 16156-52-8 n-octyl methanesulfonate 
• 111-87-5 octanol 

Downstream Products

• 111-88-6 Octanethiol 
• 822-27-5 dioctyl disulfide 

Relevant articles and documents

Amphiphilic dendrimer, synthesis method thereof, and application of amphiphilic dendrimer as drug delivery system

The invention relates to a microenvironment response type amphiphilic dendrimer, a synthesis method thereof, and application of the microenvironment response type amphiphilic dendrimer as a drug delivery system. The microenvironment response type amphiphilic dendrimer is a compound with a structure as shown in a formula (I), a formula (II) or a formula (III) or pharmaceutically acceptable salt of the compound. The compound disclosed by the invention can be used as the nano delivery system based on tumor microenvironment specific response, has good solubility in an aqueous solution, can be self-assembled with a drug in the aqueous solution to form a relatively stable nano compound, can effectively deliver the loaded drug to a tumor site; and can responsively disassembl the nano-drug delivery carrier under corresponding stimulation to achieve the purpose of accurate drug release, so that the drug can be released to the focus part to the greatest extent, and the compound is a novel nano-delivery carrier.

Efficient synthesis of organic thioacetates in water

Thioacetates as precursors of thiols are interesting starting points for synthesizing other organosulfur compounds. Herein, we propose a simple, efficient and fast method to obtain organic thioacetates using water as a solvent. Taking into account the great attention that has been paid toward environmentally friendly synthetic procedures in the past decades, we prove the role and the strength of the thioacetate anion as a nucleophile for nucleophilic displacement reactions in an aqueous medium. The reactions were carried out under pH control, to prevent the decomposition of the mesylate starting materials, using potassium carbonate as a safe and mild base. A simple work up allows products to be obtained with excellent yield and acceptable purity.

S-Acylation of aliphatic and aromatic thiols with carboxylic acids and their esters over solid acid catalysts in the gas phase at temperatures above 200 °c

Benzenethiol is reacted with acetic acid in a hydrogen stream over [(Mo6Cl8)Cl4(H2O) 2]·6H2O. Catalytic activity of the clusters appears above 200 °C, yielding S-phenyl thioacetate. The selectivity is 98% at 300 °C. Niobium, tantalum, and tungsten halide clusters with the same octahedral metal framework also catalyze the reaction. Benzoic acid and aliphatic carboxylic acids afford the corresponding S-phenyl carbothioates by reaction with benzenethiol. Aliphatic thiols are also S-acylated to yield the corresponding S-alkyl carbothioates. When carboxylic esters are applied to the reaction with benzenethiol over [(Nb6Cl12)Cl 2(H2O)4]·4H2O at 450 °C, the sterically unhindered moiety of the ester is incorporated into the products: S-phenyl thioacetate or methyl phenyl sulfide is obtained selectively. A Br?nsted acid site developed on the cluster complex by thermal activation is the active site of the catalyst. Hence, solid acids such as silica-alumina, zeolites, and heteropoly acids that are stable above 200 °C also catalyze these reactions.