24422-78-4

Basic information

• Product Name: [(1-phenylethyl)sulfonyl]benzene
• CAS NO: 24422-78-4
• Molecular Formula: C₁₄H₁₄O₂S
• Molecular Weight: 246.3248
• Mol File: 24422-78-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 417.3°C at 760 mmHg
• Flash Point: 252.7°C
• Density: 1.177g/cm³
• Vapor Pressure: 8.69E-07mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: [(1-phenylethyl)sulfonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: [(1-phenylethyl)sulfonyl]benzene(24422-78-4)
• EPA Substance Registry System: [(1-phenylethyl)sulfonyl]benzene(24422-78-4)

Safety Data

• Hazardous Substances Data: 24422-78-4(Hazardous Substances Data)

Usage

General Description

[(1-phenylethyl)sulfonyl]benzene, also known as α-phenylethylbenzenesulfonate, is a chemical compound with the molecular formula C14H14O2S. It is a white to light yellow crystalline solid that is insoluble in water. [(1-phenylethyl)sulfonyl]benzene is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it has potential applications as a building block in the production of fragrances, dyes, and other fine chemicals.[(1-phenylethyl)sulfonyl]benzene may also be used in research as a reagent for chemical reactions and as an additive in polymers and plastics. Overall, this chemical has diverse uses in various industries, making it a valuable and versatile compound.

Upstream product

• 3112-88-7 Benzyl phenyl sulfone 
• 616-38-6 carbonic acid dimethyl ester 
• 7647-01-0 hydrogenchloride 
• 3406-03-9 2-(phenylsulfonyl)acetophenone 
• 70683-04-4 α-benzenesulfonyl-phenylacetic acid 
• 74-88-4 methyl iodide 
• 40390-78-1 [(1-phenylethyl)thio]benzene 
• 108-86-1 bromobenzene 
• 599-70-2 ethyl phenyl sulfone 
• 49833-39-8 α-phenyl vinyl phenylsulfone 
• 17101-78-9 <(1-bromoethenyl)sulfonyl>benzene 
• 98-80-6 phenylboronic acid 
• 67-56-1 methanol 
• 2449-49-2 dimethyl(1-phenylethyl)amine 

Downstream Products

• 66644-32-4 [(1E)-2-iodo-1-methyl-vinyl]-benzene 
• 137195-74-5 Z-(2-iodo-1-methylethenyl)-benzene 
• 492-37-5 hydratropic acid 
• 174090-36-9 4,4,5,5-tetramethyl-2-(1-phenyl-ethyl)-[1,3,2]dioxaborolane 
• 4413-14-3 1-phenyl-1-ethylidenecyclobutane 
• 1221171-57-8 3,3-bis(3-phenylpropoxymethyl)-1-(1-phenyl)ethylidenecyclobutane 
• 51416-86-5 α-benzenesulfonyl-α-phenylpropionic acid 
• 895579-44-9 (C₄H₉)3SnC(CH₃)(C₆H₅)SO₂C₆H₅ 
• 1677-87-8 acetophenone 2,4-dinitrophenylhydrazone 
• 77815-44-2 1-phenyl-1-phenylthio-1-trimethylsilylethane 
• 107270-99-5 Methanesulfonic acid 1-benzenesulfonyl-1-phenyl-ethyl ester 
• 49833-39-8 α-phenyl vinyl phenylsulfone 
• 117582-80-6 (E)-(1-cyclohexylprop-1-en-2-yl)benzene 
• 98-86-2 acetophenone 

Relevant articles and documents

Cobalt-Catalyzed Redox-Neutral Sulfonylative Coupling from (Hetero)aryl Boronic Acids, Ammonium Salts and Potassium Metabisulfite

An efficient cobalt-catalyzed redox-neutral sulfonylative coupling to afford (hetero)aryl alkyl sulfones from boronic acids, ammonium salts and potassium metabisulfite has been realized. Commercially available and air-stable CoCl2, in combination with phenanthroline ligand, is sufficient to achieve rapid and high-yielding conversion of the reactants into the corresponding sulfones. This practical transformation proceeds smoothly through C?N bond cleavage under redox-neutral catalytic conditions and shows broad functional-group tolerance. Other carbon based electrophiles, including diaryliodonium salts, heteroaryl halides, and carbonates were compatible. Further transformation of aryl alkyl sulfones then allows conversion into olefins, alkenyl sulfones and halogenated sulfones, respectively, in a one-pot process.

Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).

An efficient and straightforward route to terminal vinyl sulfones via palladium-catalyzed Suzuki reactions of α-bromo ethenylsulfones

A general and simple protocol for the synthesis of α-substituted alkenylsulfones has been developed firstly via palladium-catalyzed Suzuki reactions between α-bromo ethenylsulfones and organoborons. Using a catalyst composed of Pd(OAc)2 and SPhos, a variety of aryl, heteroaryl, and alkylboron reagents could efficiently couple with α-bromo ethenylsulfones under mild conditions. Moreover, it has been demonstrated for the first time that vinyl sulfones underwent smooth reduction by diimide generated from 2-nitrobenzenesulfonylhydrazide.