24506-17-0

Basic information

• Product Name: 3-hydroxy-3-phenylpropanamide
• Synonyms: 3-hydroxy-3-phenylpropionamide
• CAS NO: 24506-17-0
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 24506-17-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 404.5°C at 760 mmHg
• Flash Point: 198.4°C
• Density: 1.198g/cm³
• Vapor Pressure: 2.87E-07mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 3-hydroxy-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-phenylpropanamide(24506-17-0)
• EPA Substance Registry System: 3-hydroxy-3-phenylpropanamide(24506-17-0)

Safety Data

• Hazardous Substances Data: 24506-17-0(Hazardous Substances Data)

Upstream product

• 3446-58-0 3-oxo-3-phenylpropanamide 
• 939-05-9 3-hydroxy-5-phenylisoxazole 
• 100-52-7 benzaldehyde 
• 13435-12-6 N-Trimethylsilylacetamide 
• 15463-91-9 3-bromo-3-phenylpropionic acid 
• 7664-41-7 ammonia 
• 7647-01-0 hydrogenchloride 
• 73627-97-1 3-hydroxy-3-phenylpropanenitrile 
• 614-16-4 Benzoylacetonitrile 
• 144-48-9 iodacetamide 
• 73627-97-1 (R)-3-phenyl-3-hydroxypropanenitrile 
• 198561-42-1 (R)-3-acetyloxy-3-phenylpropanenitrile 
• 72656-47-4 ethyl (R)-3-hydroxy-3-phenylpropanoate 
• 7497-61-2 methyl 3-hydroxy-3-phenylpropionate 

Downstream Products

• 37038-75-8 1-hydroxy-1-phenylpentan-3-one 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 7693-77-8 5-phenyloxazolidin-2-one 
• 621-79-4 cinnamamide 
• 621-82-9 Cinnamic acid 
• 186343-35-1 (S)-5-phenyl-1,3-oxazolidine-2-one 
• 145624-53-9 (+/-)-1-hydroxy-1-phenyl-3-heptanone 
• 7568-93-6 2-Amino-1-phenylethanol 
• 140-10-3 (E)-3-phenylacrylic acid 

Relevant articles and documents

Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations

A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles, featuring diverse substitution patterns, the scope and limitations of the process have been established.

Ruthenium-Catalyzed Synthesis of β-Hydroxyamides from β-Ketonitriles in Water

An unprecedented hydration/transfer hydrogenation tandem process for the catalytic conversion of β-ketonitriles into synthetically useful β-hydroxyamides in water has been developed, making use of the ruthenium(II) complex [RuCl2(η6-

Hydration of nitriles to amides by a chitin-supported ruthenium catalyst

Chitin-supported ruthenium (Ru/chitin) promotes the hydration of nitriles to carboxamides under aqueous conditions. The nitrile hydration can be performed on a gram-scale and is compatible with the presence of various functional groups including olefins, aldehydes, carboxylic esters and nitro and benzyloxycarbonyl groups. The Ru/chitin catalyst is easily prepared from commercially available chitin, ruthenium(III) chloride and sodium borohydride. Analysis of Ru/chitin by high-resolution transmission electron microscopy indicates the presence of ruthenium nanoparticles on the chitin support.