245649-77-8

Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 6764-10-9 4-chlorophenyl 2-nitrophenyl sulfide 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 106-54-7 p-Chlorothiophenol 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 245649-78-9 2-(4-Chlorophenylthio)-N-(4-chlorobenzenesulfonyl)-N-(2-dimethylaminoethyl)aniline.HCl 

Relevant academic research and scientific papers

Fe-based metal-organic frameworks for the synthesis of N-arylsulfonamides via the reactions of sodium arylsulfinates or arylsulfonyl chlorides with nitroarenes in water

A newly developed chemoselective reaction of sodium arylsulfinates or arylsulfonyl chlorides with nitroarenes has been disclosed. The chemistry, in which non-toxic water and recyclable iron-based metal-organic frameworks are employed as the solvent and catalyst, respectively, provides an efficient approach for the generation of N-arylsulfonamides, which are widely present in biologically active compounds and drugs, rendering this methodology attractive to both synthetic and medicinal chemistry.

Sulfonamide derivatives and drugs containing the same as the active ingredient

The present invention discloses a sulfonamide derivative represented by the following formula (1): [wherein A represents a nitrogen atom, —CH═, etc.; Z represents an oxygen atom, etc.; Ar1represents an aryl group, etc.; Ar2represents an alkyl group, etc.; Rarepresents a hydrogen atom, etc.; Rbrepresents a hydrogen atom, etc.; and Rcrepresents an alkyl group, etc.], or a salt thereof; and drugs containing the derivative or a salt thereof as an active ingredient. This compound exhibits radical scavenging action, gastric mucous secretion augmenting action, and anti-HP action, and thus is effective as a peptic ulcer therapeutic agent.