24568-13-6

Basic information

• Product Name: TIMTEC-BB SBB000703
• Synonyms: TIMTEC-BB SBB000703;N-(4-Acetylphenyl)-2,2,2-trifluoroacetamide;AcetaMide, N-(4-acetylphenyl)-2,2,2-trifluoro-;4'-Acetyl-2,2,2-trifluoroacetanilide;ACETANILIDE, 4'-ACETYL-2,2,2-TRIFLUORO-;N-(4-ethanoylphenyl)-2,2,2-trifluoro-ethanamide
• CAS NO: 24568-13-6
• Molecular Formula: C₁₀H₈F₃NO₂
• Molecular Weight: 231.17
• Mol File: 24568-13-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 332.7°Cat760mmHg
• Flash Point: 155°C
• Appearance: /
• Density: 1.356g/cm³
• Vapor Pressure: 0.000144mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: TIMTEC-BB SBB000703(CAS DataBase Reference)
• NIST Chemistry Reference: TIMTEC-BB SBB000703(24568-13-6)
• EPA Substance Registry System: TIMTEC-BB SBB000703(24568-13-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 24568-13-6(Hazardous Substances Data)

Usage

Description

TIMTEC-BB SBB000703 is a chemical compound primarily composed of hexane, a hydrocarbon in the alkane family, which is commonly used as a solvent in various industrial and laboratory applications.

Uses

Used in Chemical Industry:
TIMTEC-BB SBB000703 is used as a solvent for dissolving and extracting various substances in chemical processes due to its ability to dissolve a wide range of non-polar compounds.
Used in Pharmaceutical Industry:
TIMTEC-BB SBB000703 is used as a solvent in the manufacturing of pharmaceutical products, facilitating the dissolution and extraction of active ingredients.
Used in Laboratory Applications:
TIMTEC-BB SBB000703 is used as a solvent in laboratory settings for various analytical techniques, such as chromatography and spectroscopy, to dissolve and separate compounds for analysis.
Used in Industrial Cleaning:
TIMTEC-BB SBB000703 is used as a cleaning agent in industrial processes to remove grease, oil, and other contaminants from surfaces and equipment.
Used in Fuel Industry:
TIMTEC-BB SBB000703 may be used as a component in the production of certain types of fuels, such as gasoline, due to its hydrocarbon composition.

InChI:InChI=1/C10H8F3NO2/c1-6(15)7-2-4-8(5-3-7)14-9(16)10(11,12)13/h2-5H,1H3,(H,14,16)

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 171364-81-1 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 
• 354-38-1 2,2,2-trifluoroacetamide 
• 99-90-1 para-bromoacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 108-24-7 acetic anhydride 
• 99-92-3 p-aminobenzophenone 
• 354-32-5 trifluoracetyl chloride 

Downstream Products

• 1139857-64-9 N-[4-(1-cyano-1-hydroxyethyl)phenyl]-2,2,2-trifluoroacetamide 
• 77764-50-2 Oxo-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid ethyl ester 
• 85849-70-3 N-{4-[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-thiazol-2-yl}-oxalamic acid ethyl ester 
• 78982-82-8 rac-N-{4-[2-(tert-butylamino)-1-hydroxyethyl]phenyl}-2-chloroacetamide 
• 56138-70-6 rac-1-(4-aminophenyl)-2-(tert-butylamino)ethanol 

Relevant articles and documents

Aminoazanium of DABCO: An Amination Reagent for Alkyl and Aryl Pinacol Boronates

The aminoazanium of DABCO (H2N-DABCO) has been developed as a general and practical amination reagent for the direct amination of alkyl and aryl pinacol boronates. This compound is stable and practical for use as a reagent. Various primary, secondary. and tertiary alkyl?Bpin and aryl?Bpin substrates were aminated to give the corresponding amine derivatives. The amination is stereospecific. The anti-Markovnikov hydroamination of olefins was easily achieved by catalytic hydroboration with HBpin and in subsequent situ amination using H2N-DABCO. Moreover, the combination of 1,2-diboration of olefins, using B2pin2, with this amination process achieved the unprecedented 1,2-diamination of olefins. The amination protocol was also successfully extended to aryl pinacol boronates.

Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors

In this study, we developed 3-/4-aminoacetophenones and their structure-based 3-/4-aminophenylethylidenethiosemicarbazide derivatives, respectively, as novel tyrosinase activators and inhibitors. Notably, all the obtained thiosemicarbazones displayed more potent tyrosinase inhibitory activities than kojic acid. Especially, compound 7k was found to be the most active tyrosinase inhibitor with IC50 value of 0.291 1/4M. The structure-activity relationships (SARs) analysis showed that: (1) the amine group was absolutely necessarily for determining the tyrosinase activation activity; (2) the introduction of thiosemicarbazide group played a very vital role in transforming tyrosinase activators into tyrosinase inhibitors; (3) the phenylethylenethiosemicarbazide moiety was crucial for determining the tyrosinase inhibitory activity; (4) the type of acyl group had no obvious effect on the inhibitory activity; (5) the position of amide substituent on the phenyl ring influenced the tyrosinase inhibitory potency. Moreover, the inhibition mechanism and inhibition kinetics study revealed that compound 7k was reversible and non-competitive inhibitor, and compound 8h was reversible and competitive-uncompetitive mixed-II type inhibitor.

Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide

A catalytic method was developed to synthesize primary arylamines from the corresponding aryl bromides and iodides under mild conditions (yields = 80-99%). Crystalline 2,2,2-trifluoroacetamide was used as ammonia surrogate and CuI/N,N′-dimethyl ethylenediamine was used as catalyst to achieve the C-N cross-coupling.