24568-13-6

Usage

Uses

Used in Chemical Industry:
TIMTEC-BB SBB000703 is used as a solvent for dissolving and extracting various substances in chemical processes due to its ability to dissolve a wide range of non-polar compounds.
Used in Pharmaceutical Industry:
TIMTEC-BB SBB000703 is used as a solvent in the manufacturing of pharmaceutical products, facilitating the dissolution and extraction of active ingredients.
Used in Laboratory Applications:
TIMTEC-BB SBB000703 is used as a solvent in laboratory settings for various analytical techniques, such as chromatography and spectroscopy, to dissolve and separate compounds for analysis.
Used in Industrial Cleaning:
TIMTEC-BB SBB000703 is used as a cleaning agent in industrial processes to remove grease, oil, and other contaminants from surfaces and equipment.
Used in Fuel Industry:
TIMTEC-BB SBB000703 may be used as a component in the production of certain types of fuels, such as gasoline, due to its hydrocarbon composition.

InChI:InChI=1/C10H8F3NO2/c1-6(15)7-2-4-8(5-3-7)14-9(16)10(11,12)13/h2-5H,1H3,(H,14,16)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 407-25-0 trifluoroacetic anhydride 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 108-24-7 acetic anhydride 
• 354-38-1 2,2,2-trifluoroacetamide 
• 13329-40-3 4-Iodoacetophenone 
• 99-90-1 para-bromoacetophenone 
• 354-32-5 trifluoracetyl chloride 
• 171364-81-1 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 

Downstream Products

• 1139857-64-9 N-[4-(1-cyano-1-hydroxyethyl)phenyl]-2,2,2-trifluoroacetamide 
• 77764-50-2 Oxo-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid ethyl ester 
• 78982-82-8 rac-N-{4-[2-(tert-butylamino)-1-hydroxyethyl]phenyl}-2-chloroacetamide 
• 56138-70-6 rac-1-(4-aminophenyl)-2-(tert-butylamino)ethanol 
• 85849-70-3 N-{4-[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-thiazol-2-yl}-oxalamic acid ethyl ester 

Relevant academic research and scientific papers

Aminoazanium of DABCO: An Amination Reagent for Alkyl and Aryl Pinacol Boronates

The aminoazanium of DABCO (H2N-DABCO) has been developed as a general and practical amination reagent for the direct amination of alkyl and aryl pinacol boronates. This compound is stable and practical for use as a reagent. Various primary, secondary. and tertiary alkyl?Bpin and aryl?Bpin substrates were aminated to give the corresponding amine derivatives. The amination is stereospecific. The anti-Markovnikov hydroamination of olefins was easily achieved by catalytic hydroboration with HBpin and in subsequent situ amination using H2N-DABCO. Moreover, the combination of 1,2-diboration of olefins, using B2pin2, with this amination process achieved the unprecedented 1,2-diamination of olefins. The amination protocol was also successfully extended to aryl pinacol boronates.

Amination reagent as well as preparation method and application thereof

The invention discloses an amination reagent as well as a preparation method and application thereof. The amination reagent has a structure as shown in a formula disclosed in the invention, wherein Xis selected from any one of I, Cl, Br, NO3 and ClO4, and Y and Z are independently selected from H or alkyl with the carbon atom number of 1-4. The process for preparing the amination reagent is simple, the raw materials are easy to obtain, the cost is low, the yield is stable, and the prepared amination reagent is stable in character, can be stored at room temperature for a long time and can be taken as needed; meanwhile, the prepared amination reagent is efficient in performance, boron substrate applicability is excellent, reaction effect is good, and limitation of amination reaction of organic boron compounds on substrates is greatly expanded.

Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors

In this study, we developed 3-/4-aminoacetophenones and their structure-based 3-/4-aminophenylethylidenethiosemicarbazide derivatives, respectively, as novel tyrosinase activators and inhibitors. Notably, all the obtained thiosemicarbazones displayed more potent tyrosinase inhibitory activities than kojic acid. Especially, compound 7k was found to be the most active tyrosinase inhibitor with IC50 value of 0.291 1/4M. The structure-activity relationships (SARs) analysis showed that: (1) the amine group was absolutely necessarily for determining the tyrosinase activation activity; (2) the introduction of thiosemicarbazide group played a very vital role in transforming tyrosinase activators into tyrosinase inhibitors; (3) the phenylethylenethiosemicarbazide moiety was crucial for determining the tyrosinase inhibitory activity; (4) the type of acyl group had no obvious effect on the inhibitory activity; (5) the position of amide substituent on the phenyl ring influenced the tyrosinase inhibitory potency. Moreover, the inhibition mechanism and inhibition kinetics study revealed that compound 7k was reversible and non-competitive inhibitor, and compound 8h was reversible and competitive-uncompetitive mixed-II type inhibitor.

Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI

A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key step of the process and the optimization of the reaction conditions led to identify aqueous HI as an appropriate and selective reagent for the reductive deoxygenation of cyanohydrins. The synthetic route described a general and efficient strategy for the preparation of large libraries of phenylacetic and phenylpropionic acids derivatives.

Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide

A catalytic method was developed to synthesize primary arylamines from the corresponding aryl bromides and iodides under mild conditions (yields = 80-99%). Crystalline 2,2,2-trifluoroacetamide was used as ammonia surrogate and CuI/N,N′-dimethyl ethylenediamine was used as catalyst to achieve the C-N cross-coupling.