247179-34-6

Basic information

• Product Name: 1-(3-chlorophenyl)-2-methoxyethan-1-one
• Synonyms: 1-(3-chlorophenyl)-2-methoxyethan-1-one
• CAS NO: 247179-34-6
• Molecular Weight: 184.622
• Mol File: 247179-34-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(3-chlorophenyl)-2-methoxyethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chlorophenyl)-2-methoxyethan-1-one(247179-34-6)
• EPA Substance Registry System: 1-(3-chlorophenyl)-2-methoxyethan-1-one(247179-34-6)

Safety Data

• Hazardous Substances Data: 247179-34-6(Hazardous Substances Data)

Usage

Physical state

White powder

Usage

Production of pharmaceuticals and other organic compounds

Application

Key building block in the synthesis of various drugs

Industry

Pharmaceutical industry

Safety

Harmful if ingested, inhaled, or comes into contact with skin

Handling

Proper safety protocols should be followed when working with this compound

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 67-56-1 methanol 
• 99-02-5 3'-Chloroacetophenone 
• 108-37-2 1-bromo-3-chlorobenzene 
• 4128-76-1 methoxy acetic acid dimethylamide 
• 3938-96-3 ethyl 2-methoxyacetate 
• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 124-41-4 sodium methylate 
• 21886-56-6 3-chlorophenacyl chloride 

Downstream Products

• 59931-65-6 6-(3-chloro-phenyl)-3,4-diphenyl-pyran-2-one 
• 145876-34-2 4-(3-chlorophenyl)-5-methoxy-2-phenylpyrimidin-4(3H)-thione 
• 145876-33-1 4-(3-chlorophenyl)-5-methoxy-2-phenylpyrimidin-4(3H)-one 
• 145876-35-3 6-(3-chlorophenyl)-5-hydroxy-2-phenylpyrimidin-4(3H)-thione 
• 145876-46-6 6-(3-chlorophenyl)-5-hydroxy-2-phenylpyrimidin-4(3H)-one 

Relevant articles and documents

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Direct Synthesis of α-Alkoxy Ketones by Oxidative C–O Bond Formation

A convenient method to prepare α-alkoxy ketones has been developed by oxidative coupling of aryl methyl ketones and alcohols. With aqueous tert-butyl hydroperoxide (6.0 equiv.) as the oxidant, tetrabutylammonium iodide (20 mol-%) as the catalyst, and TsNHNH2(1.0 equiv.) as the additive, ketones underwent direct alkoxylation to give α-methoxy or α-ethoxy ketones in moderate to good yields.

Oxidative rearrangements of arylalkanones with 1H-1-hydroxy-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide, a 'green' analog of Koser's reagent

Previous methods for the conversion of arylalkanones to alkyl 2-arylesters by oxidative rearrangement utilized reagents which either produced toxic metal salts or halogenated organics as by-products. In this report, 1H-1-hydroxy-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide (HMBI) is used to effect this useful transformation, where the reduced iodine reagent is water-soluble and readily recycled.