2473-93-0

Basic information

• Product Name: 3-(3-Chlorophenyl)quinazoline-2,4(1H,3H)-dione
• Synonyms: 3-(3-Chlorophenyl)quinazoline-2,4(1H,3H)-dione;3-(3-chlorophenyl)-1H-quinazoline-2,4-dione;3-(3-chlorophenyl)-1H-quinazoline-2,4-quinone
• CAS NO: 2473-93-0
• Molecular Formula: C₁₄H₉ClN₂O₂
• Molecular Weight: 272.68646
• Mol File: 2473-93-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-Chlorophenyl)quinazoline-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-Chlorophenyl)quinazoline-2,4(1H,3H)-dione(2473-93-0)
• EPA Substance Registry System: 3-(3-Chlorophenyl)quinazoline-2,4(1H,3H)-dione(2473-93-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2473-93-0(Hazardous Substances Data)

Upstream product

• 19959-42-3 methyl 2-({[(3-chlorophenyl)amino]carbonyl}-amino)benzoate 
• 610-34-4 ethyl 2-nitrobenzoate 
• 2909-38-8 m-chlorophenyl isocyanate 
• 91-56-5 indole-2,3-dione 
• 108-42-9 3-chloro-aniline 
• 134-20-3 2-carbomethoxyaniline 
• 124-38-9 carbon dioxide 

Downstream Products

• 879616-56-5 methyl 2-[2,4-dioxo-3-(3-chlorophenyl)-3,4-dihydroquinazolin-1-yl]acetate 

Relevant articles and documents

Oxidative Rearrangement of Isatins with Arylamines Using H2O2 as Oxidant: A Facile Synthesis of Quinazoline-2,4-diones and Evaluation of Their Antibacterial Activity

A green and highly efficient synthetic method for the synthesis of quinazoline-2,4-diones with hydrogen peroxide as the terminal oxidant has been developed. The reaction features the mild reaction conditions, broad substrate scope, metal-free catalysts, and sole byproduct water. A plausible mechanism for this process was proposed. Moreover, an antibacterial activity study was performed to evaluate the antimicrobial activities towards two Gram-negative bacterial strains (Escherichia coli, and Klebsiella pneumonia) and two Gram-positive bacterial strains (Staphylococcus epidermidis, and Staphylococcus aureus) using the Broth microdilution method.

Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo[d

One-pot synthesis of quinazoline-2,4(1H,3H)-diones and 2- thioxoquinazolinones with the aid of low-valent titanium reagent

(Chemical Equation Presented) An efficient, convenient, one-pot synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolinones was accomplished in good yields via the novel reductive cyclization of ethyl 2-nitrobenzoates with isocyanates or isothioc