248255-98-3

Upstream product

• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 108-95-2 phenol 
• 29509-29-3 1-(4-methoxyphenyl)-2-phenoxyethan-1-ol 
• 26870-30-4 1-(3-methoxyphenyl)-2-phenoxyethan-1-one 
• 19513-78-1 1-(4-methoxy-phenyl)-2-phenoxy-ethanone 
• 29556-90-9 2-phenoxy-1-(4-methylphenyl)ethanol 
• 1108233-61-9 2-(2-(4-fluorophenyl)-2-oxoethoxy)benzaldehyde 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1023815-13-5 1-(4-fluorophenyl)-2-phenoxyethan-1-ol 
• 1574666-28-6 1-(4-fluorophenyl)-2-phenoxy-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanone 
• 1613483-79-6 1-(4-fluorophenyl)-2-(4-methoxyphenyl)-2-phenoxyethanone 
• 1613483-80-9 2-(3,4-dimethoxyphenyl)-1-(4-fluorophenyl)-2-phenoxyethanone 
• 1613483-83-2 ethyl 4-(2-(4-fluorophenyl)-2-oxo-1-phenoxyethyl)benzoate 
• 1613483-81-0 4-(1-(4-fluorophenoxy)-2-oxo-2-phenylethyl)benzonitrile 
• 1613483-82-1 1-(4-fluorophenyl)-2-phenoxy-2-(3-(trifluoromethyl)phenyl)ethanone 
• 1620831-67-5 1-(4-fluorophenyl)-2-phenoxy-4-(phenylsulfonyl)butan-1-one 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 108-93-0 cyclohexanol 
• 108-95-2 phenol 
• 40515-89-7 2-phenethoxybenzene 
• 721-04-0 2-phenoxy-1-phenylethanone 

Relevant academic research and scientific papers

Transformation of aryl acyloin O-alkyl and O-phenyl derivatives to ketones

The treatment of aryl acyloin (α-hydroxyketone) O-alkyl and O-phenyl derivatives with 2-3 equiv of Zn and 1-2 equiv of NH4Cl in ethanol, refluxing for 20-120 min, gave the corresponding ketones with excellent yields. Further, α,β-epoxy ketones can be efficiently transformed to β-hydroxy ketones, and 2,2-dialkoxy-1-phenyl ketone also can be dealkoxylated to 1-phenyl ketone. Copyright Taylor & Francis Group, LLC.

Cobalt-Catalyzed Reductive C-O Bond Cleavage of Lignin β-O-4 Ketone Models via in Situ Generation of the Cobalt-Boryl Species

An efficient and mild method for reductive C-O bond cleavage of lignin β-O-4 ketone models was developed to afford the corresponding ketones and phenols with PDI-CoCl2 as the precatalyst and diboron reagent as the reductant. The synthetic utility of the methodology was demonstrated by depolymerization of a polymeric model and gram-scale transformation. Mechanistic studies suggested that this transformation involves steps of carbonyl insertion, 1,2-Brook type rearrangement, β-oxygen elimination, and rate-limiting regeneration of the catalytic active Co-B species.

Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent

Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.

Lewis-acid-mediated intramolecular trifluoromethylthiolation of alkenes with phenols: Access to SCF3-containing chromane and dihydrobenzofuran compounds

A Lewis-acid-mediated intramolecular trifluoromethylthiolation of alkenes with phenols that can offer direct access to SCF3-containing chromane and dihydrobenzofuran compounds was disclosed for the first time. Numerous SCF3-containing chromanes were obtai

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

Facile and selective hydrogenolysis of β-O-4 linkages in lignin catalyzed by Pd-Ni bimetallic nanoparticles supported on ZrO2

The β-O-4 linkage in lignin can be selectively cleaved by Pd-Ni bimetallic nanoparticles supported on ZrO2 using hydrogen gas as the hydrogen donor under ambient pressure and neutral conditions. Conspicuous enhancement in activity is observed compared with single nickel and palladium catalysts based on the results of experiments and characterization. Moreover, hydrogenation of the produced phenols is tuned by adjusting the amount of NaBH4. The catalyst can be reused over ten times in the model reaction and over five times in the hydrogenolysis of lignin without an obvious change in activity and selectivity.

Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-Disubstituted benzofurans

A highly efficient palladium-catalyzed α-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cyclodehydration of the resulting α-arylated ar

Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity

Pharmacological treatment of Chagas disease is based on benznidazole, which displays poor efficacy when administered during the chronic phase of infection. Therefore, the development of new therapeutic options is needed. This study reports on the structural design and synthesis of a new class of anti-Trypanosoma cruzi thiazolidinones (4 a-p). (2-[2-Phenoxy-1-(4-bromophenyl) ethylidene)hydrazono]-5-ethylthiazolidin-4-one (4 h) and (2-[2-phenoxy-1-(4- phenylphenyl)ethylidene)hydrazono]-5-ethylthiazolidin-4-one (4 l) were the most potent compounds, resulting in reduced epimastigote proliferation and were toxic for trypomastigotes at concentrations below 10 μM, while they did not display host cell toxicity up to 200 μM. Thiazolidinone 4 h was able to reduce the in vitro parasite burden and the blood parasitemia in mice with similar potency to benznidazole. More importantly, T. cruzi infection reduction was achieved without exhibiting mouse toxicity. Regarding the molecular mechanism of action, these thiazolidinones did not inhibit cruzain activity, which is the major trypanosomal protease. However, investigating the cellular mechanism of action, thiazolidinones altered Golgi complex and endoplasmic reticulum (ER) morphology, produced atypical cytosolic vacuoles, as well as induced necrotic parasite death. This structural design employed for the new anti-T. cruzi thiazolidinones (4 a-p) led to the identification of compounds with enhanced potency and selectivity compared to first-generation thiazolidinones. These compounds did not inhibit cruzain activity, but exhibited strong antiparasitic activity by acting as parasiticidal agents and inducing a necrotic parasite cell death. Stop the cycle! The attachment of an aryl ring to the iminic carbon produced thiazolidinones that are conformationally more restricted than first-generation thiazolidinones. This enhanced the potency of antiparasitic thiazolidinones, as observed under treatment with compound 4 h where parasite development and invasion in host cells were substantially reduced. Copyright

Chiral epoxides via borane reduction of 2-haloketones catalyzed by spiroborate ester: Application to the synthesis of optically pure 1,2-hydroxy ethers and 1,2-azido alcohols

An enantioselective borane-mediated reduction of a variety of 2-haloketones with 10% spiroaminoborate ester 1 as catalyst is described. By a simple basic workup of 2-halohydrins, optically active epoxides are obtained in high yield and with excellent enantiopurity (up to 99% ee). Ring-opening of oxiranes with phenoxides or sodium azide is investigated under different reaction conditions affording nonracemic 1,2-hydroxy ethers and 1,2-azido alcohols with excellent enantioselectivity (99% ee) and in good to high chemical yield. 2011 American Chemical Society.