249504-38-9

Basic information

• Product Name: 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde
• Synonyms: 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde
• CAS NO: 249504-38-9
• Molecular Formula: C₁₁H₇FOS
• Molecular Weight: 206.2360832
• Mol File: 249504-38-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 113-114℃
• Appearance: /
• Density: 1.288
• CAS DataBase Reference: 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde(249504-38-9)
• EPA Substance Registry System: 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde(249504-38-9)

Safety Data

• Hazardous Substances Data: 249504-38-9(Hazardous Substances Data)

Usage

General Description

5-(4-Fluorophenyl)thiophene-2-carboxaldehyde is a chemical compound with a molecular formula C12H7FO. It is a yellow solid in appearance and is used in organic synthesis and pharmaceutical research. 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde is often utilized as an intermediate in the production of pharmaceuticals and agrochemicals. Its chemical structure consists of a thiophene ring with a 4-fluorophenyl group attached, as well as a carboxaldehyde functional group. 5-(4-Fluorophenyl)thiophene-2-carboxaldehyde has potential applications in the development of new drugs and in industrial manufacturing processes.

Upstream product

• 58861-48-6 2-(4-fluorophenyl)thiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 40018-26-6 1,4-dithiane-2,5-diol 
• 1443156-64-6 C₉H₆BrFO 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 352-13-6 4-flourophenylmagnesium bromide 
• 98-03-3 thiophene-2-carbaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 1195961-00-2 2-(4-((5-(4-fluorophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1149337-64-3 (Z)-3-cyclohexyl-5-{[5-(4-fluorophenyl)thiophen-2-yl]methylene}-2-thioxoimidazolidin-4-one 
• 1149337-71-2 (Z)-3-cyclohexyl-5-{[5-(4-fluorophenyl)thiophen-2-yl]methylene}imidazolidine-2,4-dione 
• 1355034-72-8 C₁₁H₈FN₃S 
• 1355034-97-7 C₂₇H₂₈FN₃O₉S 
• 1355034-98-8 C₁₉H₂₀FN₃O₅S 
• 1313397-34-0 5-((5-(4-fluorophenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one 
• 115933-30-7 5-(4-fluorophenyl)thiophene-2-carboxylic acid 
• 918487-45-3 5-(4-fluorophenyl)thiophene-2-carbonyl chloride 
• 1132832-75-7 (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone 
• 1030825-20-7 3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide 
• 58861-48-6 2-(4-fluorophenyl)thiophene 

Relevant articles and documents

Beta-amyloid protein targeting fluorescent probe, preparation and application of beta-amyloid protein targeting fluorescent probe in Alzheimer's disease

The invention discloses a beta-amyloid protein targeting fluorescent probe, preparation and application of the beta-amyloid protein targeting fluorescent probe in Alzheimer's disease. The structural formula of the fluorescent probe is as shown in formula I in the specification. The fluorescent probe disclosed by the invention is a compound taking 6-dimethylamino-1-methylquinoline as a parent structure, and the fluorescent probe has the advantages of long emission wavelength, large Stock shift, capability of specifically detecting beta amyloid protein, sensitivity to viscosity in tissue cells, and good response to the viscosity. After the fluorescent probe is combined with beta amyloid protein in the brain of a patient suffering from the Alzheimer's disease, a fluorescence signal is obviously enhanced, and the fluorescent probe can be used for detecting the beta amyloid protein and early diagnosing the Alzheimer's disease and has important guiding significance on development of diagnosis and treatment probes of the Alzheimer's disease.

Novel 2-(5-aryl)thiophen-2-yl)benzimidazoles; design, synthesis and in vitro evaluation against cercarial phase of schistosoma mansoni

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Preparation method of canagliflozin

The invention relates to a synthesis method of canagliflozin. According to the synthesis method, 4-fluorophenylboronic acid is taken as an initial raw material to be coupled with 5-bromo-thiophene-2-formaldehyde to synthesize 5-(4-fluorophenyl)thiophene-2-formaldehyde, the 5-(4-fluorophenyl)thiophene-2-formaldehyde undergoes reduction and chlorination and then undergoes Friedel-Crafts alkylation reaction with 4-bromotoluene to synthesize 2-(2-methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene, and the 2-(2-methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene undergoes condensation, etherificationand methoxyl removal with 2,3,4,6-tetra-O-trimethylsilyl-D-gluconolactone to obtain the hypoglycemic drug canagliflozin. The preparation method has the following advantages: compared with the conventional preparation methods, the synthesis process takes the 4-fluorobenzeneboronic acid as an initial raw material, so that the raw material is cheap and easy to get, the process is easy to realize industrialization, the synthesis route is short and the operation is easy; in the synthesis process, bromine is not used or butyl lithium does not need to be used twice, so that the risk of the process can be reduced; in addition, the preparation method is capable of improving the yield of canagliflozin products to 70% or more.