115933-30-7

Basic information

• Product Name: 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&
• Synonyms: 2-Carboxy-5-(4-fluorophenyl)thiophene, 1-(5-Carboxythien-2-yl)-4-fluorobenzene, 5-(4-Fluorophenyl)-2-thenoic acid;5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&
• CAS NO: 115933-30-7
• Molecular Formula: C₁₁H₇FO₂S
• Molecular Weight: 222.238
• Product Categories: Heterocyclic Building Blocks;Thiophenes;Heterocyclic Compounds;Building Blocks
• Mol File: 115933-30-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 250-254 °C(lit.)
• Boiling Point: 389.6°Cat760mmHg
• Flash Point: 189.4°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 9.09E-07mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 3.46±0.10(Predicted)
• CAS DataBase Reference: 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&(115933-30-7)
• EPA Substance Registry System: 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&(115933-30-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36-24/25-22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 115933-30-7(Hazardous Substances Data)

Usage

General Description

5-(4-Fluorophenyl)thiophene-2-carboxylic acid is a chemical compound with the molecular formula C12H7FO2S. It is a thiophene derivative containing a carboxylic acid group and a fluorophenyl substituent. This chemical is used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs for the treatment of various diseases. Additionally, it is also used in the preparation of other functionalized thiophene derivatives for a wide range of chemical and biological applications.

InChI:InChI=1/C11H7FO2S/c12-8-3-1-7(2-4-8)9-5-6-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 333793-04-7 2-methoxycarbonyl-5-(4-fluorophenyl)thiophene 
• 58861-48-6 2-(4-fluorophenyl)thiophene 
• 124-38-9 carbon dioxide 
• 5751-83-7 ethyl 5-bromothiophene-2-carboxylate 
• 1765-93-1 4-fluoroboronic acid 
• 848095-02-3 ethyl 5-(4-flurophenyl)thiophene-2-carboxylate 
• 249504-38-9 5-(4-fluorophenyl)thiophene-2-carboxaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1407546-30-8 2-chloro-2-(4-fluorophenyl)acetaldehyde 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 

Downstream Products

• 918487-45-3 5-(4-fluorophenyl)thiophene-2-carbonyl chloride 
• 1132832-75-7 (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone 
• 1030825-20-7 3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide 
• 58861-48-6 2-(4-fluorophenyl)thiophene 
• 1435685-84-9 5-(4-fluorophenyl)-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)thiophene-2-carboxamide 

Relevant articles and documents

Synthesis of carbohydrazides and carboxamides as anti-tubercular agents

A novel series of furan/thiophene carbohydrazides and carboxamides were synthesized and evaluated for anti-TB and cytotoxic activities. All the synthesized compounds were characterized using 1H and 13C NMR and mass spectral technique

Synthetic method of 2-(4-fluorophenyl) thiophene

The invention discloses a synthetic method of 2-(4-fluorophenyl) thiophene. The synthetic method comprises the following steps: 1), performing Vilsmeier-Haack reaction on 4-fluoroacetophenone under the action of solid triphosgene and N,N-dimethylfomamide to obtain 2-chloro-2-(4-fluorophenyl) acetaldehyde; 2), performing ring-closing reaction between 2-chloro-2-(4-fluorophenyl) acetaldehyde and ethyl thioglycolate under the action of alkali to obtain 5-(4-fluorophenyl) thiophene-2-carboxylic acid ethyl ester; 3), performing esterolysis on 5-(4-fluorophenyl) thiophene-2-carboxylic acid ethyl ester under the action of alkali to obtain 5-(4-fluorophenyl) thiophene-2-formic acid; and 4), preparing 2-(4-fluorophenyl) thiophene from 5-(4-fluorophenyl) thiophene-2-formic acid under the catalysis of copper powder. The invention provides a synthetic method with low-price and easily-available raw materials and mild reaction conditions for synthesis of 2-(4-fluorophenyl) thiophene, the entire reaction has no special requirements on equipment and reaction conditions, and the yield of a product is relatively high; and the synthetic method is simple and convenient to operate, can ensure the safety of operators, and has a good market prospect.

NOVEL NEUROTRYPSIN INHIBITORS

The invention relates to novel acylamino-hydroxy-benzamides of formula (I), wherein R1 is phenyl substituted by phenyl, phenoxy, phenylamino or heteroaryl, all optionally further substituted; bicyclic aryl, monocyclic heteroaryl substituted by