56570-47-9

Upstream product

• 41125-10-4 benzoylacetaldehyde sodium salt 
• 100-46-9 benzylamine 
• 13829-77-1 3-(trimethylsilyl)-1-phenyl-2-propyn-1-one 
• 3287-99-8 benzylamine hydrochloride 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 3623-15-2 phenyl propargyl ketone 
• 25039-19-4 (E)-3-morpholino-1-phenyl-2-propen-1-one 
• 93-54-9 1-Phenyl-1-propanol 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 1066-54-2 trimethylsilylacetylene 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 3306-07-8 1-benzoyl-2-chloroethene 

Downstream Products

• 34597-73-4 3-(Benzylamino)-1-phenyl-1-propanol 
• 1434475-11-2 benzyl(6-methyl-4,6-diphenyl-1,6-dihydropyridin-3-yl)(phenyl)methanone 
• 1373319-68-6 methyl 1-benzyl-3,5-diphenyl-1H-pyrrole-2-carboxylate 
• 101895-28-7 5-benzoyl-1-benzylpyridin-2(1H)-one 

Relevant academic research and scientific papers

A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism

An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studie

Copper-catalyzed carbene insertion and ester migration for the synthesis of polysubstituted pyrroles

Copper-catalyzed carbene insertion/ester migration/cyclization of enaminones and α-diazo compounds occurred efficiently to afford 2-ester polysubstituted pyrroles under mild conditions in moderate-to-good yields. Substituent functionality was well tolerated and13C-labelled experiments demonstrated 1,2-ester migration during the reaction.

COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION

The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.

Microwave-assisted palladium-catalyzed allylation of β-enaminones

A new palladium-catalyzed approach for the C-allylation of β-enaminones under microwave irradiation is reported. This methodology provides an easy access to a variety of α-allylated enaminones. The reaction takes place with the preservation of the enamine function, which is poised for further transformations towards nitrogen-containing heterocycles. Georg Thieme Verlag Stuttgart New York.

Transformation of α-substituted propanols into γ-amino alcohols through nickel-catalyzed amination on the terminal γ-carbon of propanols

A nickel-phosphine complex was found to be effective as the catalyst for the transformation of alcohols into β-enaminones, which was successively converted into γ-amino alcohols by a conventional reductant. The sequential transformation is equivalent to the carbon-nitrogen bond formation at the γ-position of saturated alcohols. Georg Thieme Verlag Stuttgart · New York.

KHSO4 assisted Michael addition-elimination reactions of formylated acetophenones in water: A facile general green synthetic route to 3-(alkyl/aralkyl/aryl)amino-1-arylprop-2-en-1-ones

A facile general green synthetic route to 3-(alkyl/aralkyl/aryl)amino-1- arylprop-2-en-1-ones in excellent yields has been developed by reacting formylated acetophenones with primary amines assisted by KHSO4 in water.

Acid-catalyzed cascade reactions of enaminones with aldehydes: C-H functionalization to afford 1, 4-dihydropyridines

An efficient acid-catalyzed approach to the synthesis of functional 1,4-dihydropyridines from the reaction of readily available enaminones with aldehydes has been developed. This methodology was realized by a cascade reaction involving first formation of divinylmethanes and subsequent intramolecular cyclization.

Ruthenium complexes of electronically coupled cyclopentadienone ligands - Catalysts for transformations of propargyl alcohols

A series of donor- and acceptor-substituted ruthenium cyclopentadienone complexes were synthesized and their catalytic activities towards propargyl alcohols focused on amination reactions have been investigated. It is shown that the substituents of the cyclopentadienone ligand determine the mode of activation of propargyl alcohols by these complexes leading to different central intermediates in catalytic cycles. Catalytic transformations of propargyl alcohols to α- or β-amino ketones, enamino ketones, α,β-unsaturated imines, ketones, alkenes and conjugated enynes could be achieved. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Ruthenium-catalyzed enaminoketone formation from propargyl alcohols

Monomeric ruthenium(0) complexes containing electronically coupled dienone ligands were found to catalyze the formation of enaminoketones from propargyl alcohols. Georg Thieme Verlag Stuttgart.

A facile route to enaminones: Synthesis of 3-alkyl/aralkyl/arylamino-1- arylprop-2-en-1-ones

Reactions of 3-dimethylamino-1-arylprop-2-en-1-ones 2 with arylamines in acetic acid at room temperature and with alkylamines or aralkylamines in refluxing ethanol give 3-arylamino-1-arylprop-2-en-1-ones 3a-j and 3-alkyl/aralkylamino-1-arylprop-2-en-1-one