25141-25-7Relevant articles and documents
EGFR-targeting fluorescence quenching probe and preparation method and application thereof
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, (2020/12/09)
The invention relates to the technical field of molecular probes, and discloses an EGFR-targeting fluorescence quenching probe and a preparation method and application thereof. The fluorescence quenching probe structurally comprises a pharmacodynamic skeleton structure, a fluorescence quenching group and a fluorescence labeling group, wherein the fluorescence labeling group is selected from BODIPYFL dye; and the fluorescence quenching group is selected from 2, 4-dinitrophenol. The pharmacodynamic skeleton structure can be combined with EGFR protein in a targeting mode, and when the quenchinggroup in the molecular probe leaves, the fluorescence labeling group can conduct specific tracing and imaging; and by means of molecular imaging, the expression process of specific cells and moleculescan be observed in real time, a target spot is traced, and therefore disease development status evaluation and accurate detection of EGFR mutation typing of lung cancer patients are achieved at the molecular pathological level.
Synthesis of some new bio-active aryl amides
Srivastava,Purohit,Srivastava,Jain,Khubchandani
, p. 358 - 359 (2007/10/02)
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