89976-75-0

Usage

Uses

Used in Pharmaceutical Industry:
6-Amino-2H-1,4-benzoxazin-3(4H)-one is used as a potential anti-cancer agent due to its ability to target and inhibit the growth of cancer cells. Its unique chemical structure allows it to interact with cellular components, making it a promising candidate for the development of novel cancer therapies.
Used in Agrochemical Industry:
6-Amino-2H-1,4-benzoxazin-3(4H)-one is used as a natural defense compound in plants, playing a crucial role in protecting them from pests and diseases. Its potential use in agrochemicals can help develop environmentally friendly and effective pest control solutions.
Used in Research and Development:
6-Amino-2H-1,4-benzoxazin-3(4H)-one is utilized in various research fields due to its unique chemical properties and potential applications. It serves as a subject of interest for scientists working on the development of new pharmaceuticals, agrochemicals, and other innovative solutions.

InChI:InChI=1/C8H8N2O2/c9-5-1-2-7-6(3-5)10-8(11)4-12-7/h1-3H,4,9H2,(H,10,11)

Upstream product

• 90814-92-9 N-(3-oxo-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-acetamide 
• 25141-25-7 2,4-dinitrophenoxyacetic acid 
• 81721-87-1 6-nitro-4H-benzo[1,4]oxazin-3-one 
• 2298-36-4 4-aminophenoxyacetic acid 
• 100135-98-6 (4-acetylamino-2-nitro-phenoxy)-acetic acid ethyl ester 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 598-42-5 glycolamide 
• 95-76-1 m,p-dichloroaniline 
• 85196-33-4 ethyl 2,4-dinitrophenoxyacetate 
• 67-56-1 methanol 

Downstream Products

• 90814-94-1 N-(3-oxo-3,4-dihydro-2H-benz[1,4]oxazin-6-yl)-benzamide 
• 31794-45-3 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonyl chloride 
• 27320-80-5 6-Sulfamoyl-2H-1,4-benzoxazin-3-on 
• 866132-09-4 C₁₅H₁₂N₂O₄ 
• 888038-17-3 1-phenyl-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 26011-57-4 3,4-Dihydro-2H-benzo[1,4]oxazin-6-ylamine 
• 1025717-56-9 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-6-yl)-4-methylbenzamide trifluoroacetate 
• 1030755-71-5 8-(2-hydroxybenzoyl)-2H-[1,4]oxazino[2,3-g]quinolin-3(4H)-one 
• 888038-29-7 1-(2-Fluoro-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 888038-30-0 1-(2-Chloro-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 888038-31-1 1-(2-Bromo-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 888038-43-5 1-(2-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 888038-20-8 1-(2-Ethyl-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 
• 888038-21-9 1-(2-Isopropyl-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 6-AMINO-2H-1,4-BENZOXAZINE-3(4H)-ONE

PROBLEM TO BE SOLVED: To provide an industrially advantageous production method for 6-amino-2H-1,4-benzoxazine-3(4H)-one. SOLUTION: A method for producing 6-amino-2H-1,4-benzoxazine-3(4H)-one includes contact reduction and cyclization of the following compound, using a catalyst containing one or more metal atom selected from the group consisting of iron, cobalt, nickel and copper (R1 is a C1-C6 alkyl group; R2, R3 and R4 are the same or different to denote a C1-C6 alkyl group, a halogen atom or H). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

NITROGEN-CONTAINING BIOPOLYMER-BASED CATALYSTS, THEIR PREPARATION AND USES IN HYDROGENATION PROCESSES, REDUCTIVE DEHALOGENATION AND OXIDATION

The present invention relates to a process for the preparation of a nitrogen containing biopolymer-based catalyst by pyrolysis of a metal complex with a nitrogen-containing biopolymer and to the nitrogen containing biopolymer-based catalysts obtainable by this process. In particular, the invention relates to a nitrogen containing biopolymer-based catalyst comprising metal particles and at least one nitrogen containing carbon layer. The invention also relates to the use of a nitrogen containing biopolymer-based catalyst in a hydrogenation process, preferably in a process for hydrogenation of nitroarenes, nitriles or imines; in a reductive dehalogenation process of C-X bonds, wherein X is CI, Br or I, preferably in a process for dehalogenation of organohalides or in a process for deuterium labelling of arenes via dehalogenation of organohalides; or in an oxidation process. Further, the invention relates to a metal complex with the nitrogen containing biopolymer, wherein the metal is a transition metal selected from the group consisting of manganese, ruthenium, cobalt, rhodium, nickel, palladium and platinum, preferably cobalt or nickel, and wherein the nitrogen containing biopolymer is selected from chitosan, chitin and a polyamino acid, preferably chitosan or chitin.

NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS FAK/AURORA KINASE INHIBITORS

This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer.

METHOD OF PRODUCING 6-AMINO-2H-1,4-BENZOXAZINE-3(4H)-ONES

PROBLEM TO BE SOLVED: To provide an industrially advantageous method of producing 6-amino-2H-1,4-benzoxazine-3(4H)-ones. SOLUTION: There is provided a method of producing a compound represented by formula (2) by catalytic reduction and cyclization of a compound represented by formula (1), where R1 is C1-C6 alkyl, and R2-R4 are C1-C6 alkyl, halogen or H. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Synthesis technology of 1,4-benzoxazinone compound

The invention relates to a synthesis technology of benzoxazinone compounds represented by formula I. The technology is characterized in that a dichlorobenzene derivative represented by formula II reacts with ethanolamide represented by formula III in the presence of a catalyst and an inorganic alkali to obtain the compound of formula I. R in the formula I and the formula II is selected from hydrogen, an amino group, a nitro group, a C1-6 alkyl group, a C1-6 alkoxy group and a hydroxyl group. The technology is a one-pot reaction method, realizes one-step direct cyclization, and has the advantages of simple reaction conditions, convenience in treatment, safe and highly-effective process, and high yield.

Biomass-Derived Catalysts for Selective Hydrogenation of Nitroarenes

Development of catalytically active materials from biowaste represents an important aspect of sustainable chemical research. Three heterogeneous materials were synthesized from inexpensive biomass-based chitosan and abundant Co(OAc)2 using complexation followed by pyrolysis at various temperatures. These materials were applied in the catalytic hydrogenation of nitroarenes using molecular hydrogen. A variety of diversely functionalized nitroarenes including some pharmaceutically active compounds were converted into aromatic amines in high yields, with high selectivity, and with excellent functional group tolerance. This green protocol has also been implemented for the synthesis of a biologically important TRPC3 inhibitor.

Synthetic technology for preparing 1,4-benzoxazinone through microwave process

The invention relates to a preparation method for a benzoxazine compound. The method comprises the following steps: adding the compound shown as formula II, methyl alcohol and catalyst into a reactor; reacting under the existence of catalyst and alkali; and performing post-processing after ending the reaction, thereby acquiring the compound shown as formula I. In the formula, R group is selected from hydrogen, amino, nitro, C1-C6 alkyl, C1-C6 alkoxy and hydroxy; alkyl is selected from methyl, ethyl and isopropyl; alkoxy is selected from methoxy group, ethyoxyl and isopropoxy. The method is low in cost of raw materials, is safe and reliable, is completed under normal temperature and normal pressure and is simple in process.

Mild and selective hydrogenation of nitro compounds using palladium nanoparticles supported on amino-functionalized mesocellular foam

We present the utilization of a heterogeneous catalyst comprised of Pd nanoparticles supported on aminopropyl-functionalized siliceous mesocellular foam (Pd0-AmP-MCF) for the selective hydrogenation of aromatic, aliphatic, and heterocyclic nitro compounds to the corresponding amines. In general, the catalytic protocol exclusively affords the desired amine products in excellent yields within short reaction times with the reactions performed at room temperature under ambient pressure of H2. Moreover, the reported Pd nanocatalyst displayed excellent structural integrity for this transformation as it could be recycled multiple times without any observable loss of activity or leaching of metal. In addition, the Pd nanocatalyst could be easily integrated into a continuous-flow device and used for the hydrogenation of 4-nitroanisole on a 2.5 g scale, where the product p-anisidine was obtained in 95% yield within 2 h with a Pd content of less than 1 ppm.

COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES

The present invention provides arylpiperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.

Compositions, Synthesis, And Methods Of Using Piperazine Based Antipsychotic Agents

The present invention provides novel piperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.