89976-75-0Relevant articles and documents
METHOD FOR PRODUCING 6-AMINO-2H-1,4-BENZOXAZINE-3(4H)-ONE
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Paragraph 0019-0020; 0025; 0027, (2020/04/01)
PROBLEM TO BE SOLVED: To provide an industrially advantageous production method for 6-amino-2H-1,4-benzoxazine-3(4H)-one. SOLUTION: A method for producing 6-amino-2H-1,4-benzoxazine-3(4H)-one includes contact reduction and cyclization of the following compound, using a catalyst containing one or more metal atom selected from the group consisting of iron, cobalt, nickel and copper (R1 is a C1-C6 alkyl group; R2, R3 and R4 are the same or different to denote a C1-C6 alkyl group, a halogen atom or H). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS FAK/AURORA KINASE INHIBITORS
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Page/Page column 37, (2018/02/28)
This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer.
Synthesis technology of 1,4-benzoxazinone compound
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Paragraph 0025-0027; 0037-0046, (2018/03/26)
The invention relates to a synthesis technology of benzoxazinone compounds represented by formula I. The technology is characterized in that a dichlorobenzene derivative represented by formula II reacts with ethanolamide represented by formula III in the presence of a catalyst and an inorganic alkali to obtain the compound of formula I. R in the formula I and the formula II is selected from hydrogen, an amino group, a nitro group, a C1-6 alkyl group, a C1-6 alkoxy group and a hydroxyl group. The technology is a one-pot reaction method, realizes one-step direct cyclization, and has the advantages of simple reaction conditions, convenience in treatment, safe and highly-effective process, and high yield.