25176-55-0Relevant academic research and scientific papers
Ferric Salt Catalyzed Oxygenation of Cycloalkanones to Oxo Esters by Molecular Oxygen
Ito, Satoru,Matsumoto, Masakatsu
, p. 1133 - 1135 (1983)
Ferric salts catalyzed the regiospecific oxygenation of cycloalkanones by molecular oxygen to give oxo esters in the presence of aliphatic alcohol under mild conditions.
IONIZABLE AMINE LIPIDS AND LIPID NANOPARTICLES
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Page/Page column 126; 127, (2020/11/04)
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
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Page/Page column 98, (2015/07/07)
This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, n and p are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
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Page/Page column 109, (2015/07/07)
This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
Introducing an in situ capping strategy in systems biocatalysis to access 6-aminohexanoic acid
Sattler, Johann H.,Fuchs, Michael,Mutti, Francesco G.,Grischek, Barbara,Engel, Philip,Pfeffer, Jan,Woodley, John M.,Kroutil, Wolfgang
supporting information, p. 14153 - 14157 (2015/02/19)
The combination of two cofactor self-sufficient biocatalytic cascade modules allowed the successful transformation of cyclohexanol into the nylon-6 monomer 6-aminohexanoic acid at the expense of only oxygen and ammonia. A hitherto unprecedented carboxylic acid capping strategy was introduced to minimize the formation of the deadend intermediate 6-hydroxyhexanoic acid. For this purpose, the precursor ε-caprolactone was converted in aqueous medium in the presence of methanol into the corresponding methyl ester instead of the acid. Hence, it was shown for the first time that esterases-specifically horse liver esterase-can perform the selective ring-opening of ε-caprolactone with a clear preference for methanol over water as the nucleophile.
Designer discodermolide segments via ozonolysis of vinyl phosphonates
Du Jourdin, Xavier Mollat,Noshi, Mohammad,Fuchs
supporting information; experimental part, p. 543 - 546 (2009/07/18)
(Chemical Equation Presented) To apply our collection of enantiopure 7-ring vinyl sulfones to probe the anticancer SAR of a series of computer-designed (+)-discodermolide analogs, the ozonolytic reactivity of transposed cyclic vinyl phosphonates was explo
Efficient and selective catalytic oxidative cleavage of α-hydroxy ketones using vanadium-based HPA and dioxygen
El Aakel,Launay,Atlamsani,Bregeault
, p. 2218 - 2219 (2007/10/03)
The combination of H3 + n[PMo12 - nVnO 40]·aq (HPA-n, n = 3) and dioxygen provides a clean and regioselective reagent for the homolytic cleavage of various representative α-hydroxy ketones (primary to tertiary) and turns out to be as efficient for the catalytic ring opening of chiral natural products.
Photo-cleavage of carbon-carbon bond of α-iodocycloalkanones giving ω,ω-dialkoxyalkanoic ester in alcohol
Ji, Shun-Jun,Horiuchi, C. Akira
, p. 1645 - 1652 (2007/10/03)
The irradiation at λ > 300 nm of α-iodocycloalkanones with a high- pressure mercury lamp in alcohols containing a small amount of water afforded the corresponding ω,ω-dialkoxyalkanoic ester (65-88%) by photochemical cleavage of the C(I)-C=O bond at room temperature. In the case of a commercial fluorescent lamp as the irradiating light source, photochemical ring-opening products were also obtained. The irradiation of 2α-iodo-5α- and 4β-iodo-5β-cholestan-3-ones in methanol gave methyl 2,2-dimethoxy-2,3- seco-5α-cholestan-3-oate and methyl 4,4-dimethoxy-3,4-seco-5β-cholestan-3- oate in 78 and 62% yields, respectively. The photochemical behavior of the cleavage reaction of α-iodocycloalkanones is also discussed on the basis of 2-hydroxycycloalkanone as an intermediate.
Electrochemical transformations of monooxa- and dioxabicycloalkenes and -bicycloalkanes
Ogibin,Terent'ev,Ilovaisky,Nikishin
, p. 2091 - 2099 (2007/10/03)
Electrolysis of 2-oxa-and 2,5-dioxabicyclo[n.4.0]alk-1(6)-enes (n = 4, 10) under conditions of direct undivided anodic oxidation in methanol results in their electrochemical mono-and dimethoxylation; electrolysis of the corresponding 2-oxa-and 2,5-dioxabicycloalkanes involves electrochemical cleavage of the bridging carbon - carbon bonds followed by electrooxidative transformation into methyl ω-(2-methoxytetrahydrofuryl)-, ω-(dimethoxymethyl)-, and ω-(1,3-dioxolan-2-yl)alkanoates.
Synthesis of glycoconjugate vaccines against Shigella dysenteriae type 1
Pozsgay, Vince
, p. 5983 - 5999 (2007/10/03)
Syntheses of hexadecasaccharide and smaller fragments corresponding to one-four repeating units of the O-specific polysaccharide of Shigella dysenteriae type 1 are reported in a reactive aglycon-linked from. Two tetrasaccharide donor/acceptor repeating units were assembled from monosaccharide precursors in a stepwise fashion and used in a linear, iterative manner to construct the higher-membered saccharides using Schmidt's glycosylation technique that proved superior to others tested. Single-point attachment of the saccharides to human serum albumin, using a secondary heterobifunctional spacer, afforded a range of glycoconjugates for a detailed evaluation of their immunological characteristics.
