252025-50-6

Basic information

• Product Name: 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, methyl ester
• CAS NO: 252025-50-6
• Molecular Formula: C16H12Cl2N2O2
• Molecular Weight: 335.189
• Mol File: 252025-50-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, methyl ester(252025-50-6)
• EPA Substance Registry System: 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, methyl ester(252025-50-6)

Safety Data

• Hazardous Substances Data: 252025-50-6(Hazardous Substances Data)

Usage

Chemical class

Indazole derivatives

Structure

Methyl ester of 1H-indazole-3-carboxylic acid with a 2,4-dichlorophenylmethyl group

Potential medicinal properties

Yes

Areas of potential application

Antimicrobial, anticancer, and anti-inflammatory drugs

Current status

Being studied for potential use in pharmaceuticals

Need for further research

Yes, to fully understand its properties and potential uses in the pharmaceutical industry.

Upstream product

• 34966-49-9 methyl 2-chlorobenzoylformate 
• 35022-42-5 2-chlorobenzoyl cyanide 
• 1403825-55-7 methyl 2-(2-chlorophenyl)-2-(2-(2,4-dichlorobenzyl)hydrazono)acetate 
• 67-56-1 methanol 
• 50264-69-2 lonidamine 
• 43120-28-1 methyl 1H-indazole-3-carboxylate 
• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 94-99-5 2,4-Dichlorobenzyl chloride 

Downstream Products

• 920019-58-5 (1-(2,4-dichlorobenzyl)-1H-indazol-3-yl)methanol 
• 252025-52-8 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide 
• 50264-69-2 lonidamine 

Relevant articles and documents

Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators

The discovery of novel modulators of the cannabinoid system is a current topic in medicinal chemistry. In this paper, we report nine novel carboxamides designed as hybrids of Fubinaca family compounds and Rimonabant. These hybrids were obtained by linking the 1-benzyl-2,5-dichloroindazole-3-carboxylic acid to different amino acids bearing a hydrophobic side chain and three different C-terminus. The new chemical entities were tested in vitro to evaluate their bioactivity by means of receptor binding assays and [35S]GTPγS stimulation assays to reveal their affinity and potency. We found that all compounds were able to bind to the cannabinoid receptors in the low nanomolar range with a marked selectivity towards the CB1 cannabinoid receptor. Some of them are full agonists, whereas the others act as partial agonists. These molecules could be potentially used as anti-obesity agents, antiemetic and analgesics.

Total syntheses of AF-2785 and gamendazole-experimental male oral contraceptives

Both AF-2785 and gamendazole are experimental male oral contraceptives. The total syntheses of these two compounds are achieved in good yields. Copyright

Lonidamine analogues and their use in male contraception and cancer treatment

Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.