920019-58-5

Basic information

• Product Name: 1H-Indazole-3-methanol, 1-[(2,4-dichlorophenyl)methyl]-
• CAS NO: 920019-58-5
• Molecular Formula: C15H12Cl2N2O
• Molecular Weight: 307.179
• Mol File: 920019-58-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indazole-3-methanol, 1-[(2,4-dichlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-3-methanol, 1-[(2,4-dichlorophenyl)methyl]-(920019-58-5)
• EPA Substance Registry System: 1H-Indazole-3-methanol, 1-[(2,4-dichlorophenyl)methyl]-(920019-58-5)

Safety Data

• Hazardous Substances Data: 920019-58-5(Hazardous Substances Data)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 615-43-0 2-iodophenylamine 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 64132-13-4 3-(hydroxymethyl)-1H-indazole 
• 99233-20-2 α-hydroxy-2-bromoacetophenone 
• 2142-69-0 2-bromophenyl methyl ketone 
• 252025-50-6 methyl 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylate 
• 1403825-55-7 methyl 2-(2-chlorophenyl)-2-(2-(2,4-dichlorobenzyl)hydrazono)acetate 
• 35022-42-5 2-chlorobenzoyl cyanide 
• 34966-49-9 methyl 2-chlorobenzoylformate 

Downstream Products

• 252025-49-3 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbaldehyde 
• 50264-69-2 lonidamine 

Relevant articles and documents

Bis(dibenzylideneacetone)palladium(0)/tert-Butyl Nitrite- Catalyzed Cyclization of o-Alkynylanilines with tert-Butyl Nitrite: Synthesis and Applications of Indazole 2-Oxides

An efficient method for the synthesis of 1-benzyl/arylindazole 2-oxides via a bis(dibenzylideneacetone)palladium(0) [Pd(dba)2]/tert-butyl nitrite (TBN)-catalyzed reaction of o-alkynylaniline derivatives with TBN is reported. The overall transfo

Copper(I) Oxide-Mediated Cyclization of o-Haloaryl N-Tosylhydrazones: Efficient Synthesis of Indazoles

An efficient synthesis of indazoles from readily accessible E/Z mixtures of o-haloaryl N-tosylhydrazones has been developed. The thermo-induced isomerization of N-tosylhydrazones is discussed. A series of valuable indazole derivatives are prepared in good yields, and the method has been successfully applied to the synthesis of the bioactive compounds, lonidamine, AF-2785, axitinib, YC-1 and YD-3.

NOVEL 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40

The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.