25216-70-0

Basic information

• Product Name: methyl N-(2-bromophenyl)carbamate
• Synonyms: methyl N-(2-bromophenyl)carbamate
• CAS NO: 25216-70-0
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 25216-70-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl N-(2-bromophenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(2-bromophenyl)carbamate(25216-70-0)
• EPA Substance Registry System: methyl N-(2-bromophenyl)carbamate(25216-70-0)

Safety Data

• Hazardous Substances Data: 25216-70-0(Hazardous Substances Data)

Usage

Uses

Methyl 2-bromophenylcarbamate preparation of quinazolinyl norepinephrine reuptake inhibitors for the treatment of central nervous system disorders.

Upstream product

• 88-65-3 2-bromobenzoic-acid 
• 79-22-1 methyl chloroformate 
• 615-36-1 2-bromoaniline 
• 681-84-5 tetramethylorthosilicate 
• 124-38-9 carbon dioxide 
• 67-56-1 methanol 
• 4001-73-4 2-Bromobenzamide 
• 7154-66-7 2-bromobenzoic acid chloride 
• 1592-00-3 2-bromophenyl isocyanate 

Downstream Products

• 851012-55-0 4-(2-Fluoro-phenyl)-1H-quinazolin-2-one 
• 116525-60-1 methyl (2-(phenylethynyl)phenyl)carbamate 

Relevant articles and documents

Chiral Bifunctional Phosphine-Carboxylate Ligands for Palladium(0)-Catalyzed Enantioselective C?H Arylation

Previous enantioselective Pd0-catalyzed C?H activation reactions proceeding via the concerted metalation-deprotonation mechanism employed either a chiral ancillary ligand, a chiral base, or a bimolecular mixture thereof. This study describes th

Synthesis of carbamates from carbon dioxide promoted by organostannanes and alkoxysilanes

A cooperative methoxy transfer between orthosilicate esters and organotin oxides was developed for the synthesis of various N-alkyl and N-aryl carbamates from carbon dioxide in up to 97% isolated yield. The reaction is highly selective and N-alkylated amines are not observed. Density functional theory calculations of the reaction were performed and, together with NMR observations, a plausible mechanism featuring the catalytic regeneration of dialkyltin dialkoxide is proposed.

Efficient synthesis of methyl carbamate via Hofmann rearrangement in the presence of TsNBr2

An efficient method has been developed for the synthesis of carbamates from the corresponding amides via the Hofmann rearrangement using N,N-dibromo-p-toluenesulfonamide (TsNBr2) in the presence of DBU in methanol. The reaction goes into completion in 10-20 min at 65 °C to produce the corresponding carbamate in excellent yield.