2522-81-8

Basic information

• Product Name: pibecarb
• Synonyms: pibecarb;2,2-Dimethylpropanoic acid 2-oxo-2-phenylethyl ester;Noscanol;(2-oxo-2-phenyl-ethyl) 2,2-dimethylpropanoate;(2-oxo-2-phenylethyl) 2,2-dimethylpropanoate;2,2-dimethylpropionic acid (2-keto-2-phenyl-ethyl) ester
• CAS NO: 2522-81-8
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.29
• EINECS: 219-749-1
• Mol File: 2522-81-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 62.5°C
• Boiling Point: 321.2°C (rough estimate)
• Flash Point: 131.5°C
• Appearance: /
• Density: 1.1101 (rough estimate)
• Vapor Pressure: 0.000749mmHg at 25°C
• Refractive Index: 1.5090 (estimate)
• CAS DataBase Reference: pibecarb(CAS DataBase Reference)
• NIST Chemistry Reference: pibecarb(2522-81-8)
• EPA Substance Registry System: pibecarb(2522-81-8)

Safety Data

• Hazardous Substances Data: 2522-81-8(Hazardous Substances Data)

Usage

Uses

Pibecarb is a drug product or related compound.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

InChI:InChI=1/C13H16O3/c1-13(2,3)12(15)16-9-11(14)10-7-5-4-6-8-10/h4-8H,9H2,1-3H3

Upstream product

• 108-86-1 bromobenzene 
• 98-86-2 acetophenone 
• 3282-30-2 pivaloyl chloride 
• 18997-19-8 Chloromethyl pivalate 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 373392-28-0 trimethylacetic acid 1-phenylallyl ester 
• 532-27-4 1-chloroacetophenone 
• 75-98-9 Trimethylacetic acid 
• 70-11-1 α-bromoacetophenone 
• 98-88-4 benzoyl chloride 
• 53064-79-2 iodomethyl pivaloate 
• 85664-75-1 2,2-Dimethyl-propionic acid 2-[(E)-tert-butylimino]-1-phenyl-ethyl ester 
• 3282-32-4 2-diazo-acetophenone 

Downstream Products

• 42052-51-7 3-hydroxy-1,3-diphenylpropan-1-one 
• 5543-97-5 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one 
• 55681-31-7 2-(4-methoxyphenyl)-1,2-diphenylethanol 
• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 79560-18-2 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid 
• 16343-36-5 2-(4-methoxy-phenyl)-2-phenylacetaldehyde 

Relevant articles and documents

α,α-Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1-Diarylethenes and α,α-Diaryl Acetaldehydes

Towards assembling of diarylmethine unit present in biologically important molecules, we have developed a new Weinreb Amide (WA) based building block derived from glycolic acid. The WA functionality present in this building block permits the sequential addition of various arylmagnesium bromide reagents in a controlled manner that enables assembly of a diarylmethine unit. The developed synthetic route provides easy access to important diarylethenes and α,α-diarylethylene glycols. The synthesized α,α-diarylethylene glycols provide access to synthetically important symmetrical and unsymmetrical α,α-diaryl acetaldehydes as valuable intermediates.

Synergistic interplay of a non-heme iron catalyst and amino acid coligands in H2O2 activation for asymmetric epoxidation of α-alkyl-substituted styrenes

Highly enantioselective epoxidation of α-substituted styrenes with aqueous H2O2 is described by using a chiral iron complex as the catalyst and N-protected amino acids (AAs) as coligands. The amino acids synergistically cooperate with the iron center in promoting an efficient activation of H2O2 to catalyze epoxidation of this challenging class of substrates with good yields and stereoselectivities (up to 97% ee) in short reaction times.

Arylation of α-pivaloxyl ketones with arylboronic reagents via Ni-catalyzed sp3 C-O activation

A Suzuki-Miyaura coupling of α-pivaloxyl ketones via Ni-catalyzed sp3 C-O activation to produce α-aryl ketones is developed. This study offers a convenient method to construct α-arylation products from readily available α-hydroxyl carbonyl compounds.