25341-38-2

Upstream product

• 13404-00-7 (E)-α,β-Diphenylacrylsaeure-dimethylamid 
• 7089-34-1 ((E)-3-Dimethylamino-2-phenyl-allylidene)-dimethyl-ammonium; perchlorate 
• 591-51-5 phenyllithium 
• 1483-82-5 phenylethynyl chloride 
• 100-52-7 benzaldehyde 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 4604-65-3 1-dimethylamino-2-phenyl-ethyne 
• 501-65-5 diphenyl acetylene 
• 75-50-3 trimethylamine 

Downstream Products

• 25341-39-3 (2,3-diphenyl-allyl)-dimethyl-amine 

Relevant academic research and scientific papers

Stereoselective Synthesis of Tertiary Allylic Amines by Titanium-Catalyzed Hydroaminoalkylation of Alkynes with Tertiary Amines

Intermolecular hydroaminoalkylation reactions of symmetrical and unsymmetrical alkynes with tertiary amines take place in the presence of catalytic amounts of TiBn4, Ph3C[B(C6F5)4], and a sterically demanding aminopyridinato ligand precursor. The resulting products, synthetically and pharmaceutically useful tertiary β,γ-disubstituted allylic amines, are formed in convincing yields and with excellent stereoselectivity. Particularly promising for future applications is the fact that even the industrial side product trimethylamine can be used as a substrate.

A CONVENIENT, ONE-POT SYNTHESIS OF 2,3-DISUBSTITUTED ALLYLIC AMINES

A series of organometallic reagents have been added to a 2-arylsubstituted vinamidinium perchlorate.The resulting reaction mixture was treated with borane or diisobutylaluminum hydride solution to produce a series of 3-substituted 2-aryl-N,N-dimethyl allylic amines.The overall one-pot procedure constitutes a convenient synthesis of 2,3-disubstituted allylic amines.