253597-40-9

Basic information

• Product Name: (E)-3-(4-Acetylphenyl)-1-phenyl-prop-2-en-1-on
• Synonyms: (E)-3-(4-Acetylphenyl)-1-phenyl-prop-2-en-1-on
• CAS NO: 253597-40-9
• Molecular Weight: 250.297
• Mol File: 253597-40-9.mol

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-Acetylphenyl)-1-phenyl-prop-2-en-1-on(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-Acetylphenyl)-1-phenyl-prop-2-en-1-on(253597-40-9)
• EPA Substance Registry System: (E)-3-(4-Acetylphenyl)-1-phenyl-prop-2-en-1-on(253597-40-9)

Safety Data

• Hazardous Substances Data: 253597-40-9(Hazardous Substances Data)

Upstream product

• 13329-40-3 4-Iodoacetophenone 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 936-59-4 3-chloropropiophenone 
• 583-06-2 3-benzoylacrylic acid 
• 99-90-1 para-bromoacetophenone 
• 4360-68-3 2-(4-bromophenyl)-2-methyl-1,3-dioxolane 
• 14490-45-0 4-(2-methyl-1,3-dioxolan-2-yl)benzaldehyde 
• 98-86-2 acetophenone 

Relevant articles and documents

Synthesis of chalcones via domino dehydrochlorination/Pd(OAc)2-catalyzed Heck reaction

A new method has been developed for the cross-coupling of aryl halides with β-chloroalkyl aryl ketones and their ester and amide analogs through a domino dehydrochlorination/Pd(OAc)2- catalyzed Heck reaction sequence. The enone intermediates generated in situ reduced the occurrence of side reactions and therefore enhanced the efficiency of the reaction. This reaction exhibited good tolerance to various functional groups on both substrates and provides rapid access to a wide range of chalcone derivatives.

Palladium-catalyzed decarboxylative arylation of benzoylacrylic acids toward the synthesis of chalcones

It has been found that readily available 3-benzoylacrylic acids undergo palladium-catalyzed decarboxylative arylation with arylboronic acids in the presence of a copper salt oxidant to produce chalcone derivatives. The decarboxylative arylation could also be achieved using aryl halides as the alternative aryl source to expand the applicable scope.

A new Heck reaction modification using ketone Mannich bases as enone precursors: Parallel synthesis of anti-leishmanial chalcones

A new Heck-type reaction for the synthesis of chalcones has been established using Mannich bases as enone precursors. The novel reaction proceeds rapidly in air atmosphere under ligandless conditions and can be adapted for library synthesis in a parallel reactor station. Screening of the synthesized chalcones revealed N-{4-[(1E)-3-oxo-3-(3-pyridinyl)-1-propenyl]phenyl}benzamide (3f) to be a potent anti-leishmanial agent.

Convergence of absorption and fluorescence in cross-conjugated oligomers consisting of chalcone building blocks

The absorption and fluorescence spectra of two series of chalcone oligomers (1a-d) and (2a-d) are reported. Due to small or vanishing orbital coefficients (HMO calculation) within the cross-conjugated systems, the bathochromic shifts caused by the extensi