77223-58-6Relevant academic research and scientific papers
PROCESS FOR THE SYNTHESIS OF IBANDRONATE SODIUM
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Page/Page column 6, (2010/08/07)
The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).
REAGENT AND USE THEREOF FOR THE PRODUCTION OF BISPHOSPHONATES
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Page/Page column 9, (2008/12/05)
A new liquid reagent is disclosed in form of an ionic liquid containing phosphorous acid and a tertiary amine. The reagent can be used as a replacement of phosphorous acid, where the new reagent as a liquid reagent can be handled using usual equipment for handling liquids and the dosing of the reagent can therefore be controlled more precisely in industrial plants compared to phosphorous acid, which is a solid at ambient temperature. The new liquid reagent is particular suitable for the synthesis of bisphosphonates.
