2547-63-9Relevant academic research and scientific papers
Generation and Reactivity of Amidyl Radicals: Manganese-Mediated Atom-Transfer Reaction
Li, Jinxia,Li, Ping,Liu, Run-Zhou,Liu, Xian-Guan,Qu, Shuanglin,Sun, Jun,Zhang, Bo
, p. 4428 - 4433 (2020)
A simple and efficient protocol to generate amidyl radicals from amine functionalities through a manganese-mediated atom-transfer reaction has been developed. This approach employs an earth-abundant and inexpensive manganese complex, Mn2(CO)su
Direct Synthesis of α-Amino Nitriles from Sulfonamides via Base-Mediated C-H Cyanation
Shi, Shasha,Yang, Xianyu,Tang, Man,Hu, Jiefeng,Loh, Teck-Peng
supporting information, p. 4018 - 4022 (2021/05/26)
Herein, we disclose a transition-metal-free reaction system that enables α-cyanation of sulfonamides through C-H bond cleavage for the preparation of α-amino nitriles, including difficult-to-access all-alkyl α-tertiary scaffolds. More than 50 substrate examples prove a wide functional group tolerance. Additionally, its synthetic practicality is highlighted by gram-scalability and the late-stage modification of natural compounds. Mechanistic experiments suggest that this process involves in situ formation of an imine intermediate via base-promoted elimination of HF.
Visible-light-promoted remote C(sp3)-H amidation and chlorination
Qin, Qixue,Yu, Shouyun
supporting information, p. 1894 - 1897 (2015/04/27)
A visible-light-promoted C(sp3)-H amidation and chlorination of N-chlorosulfonamides (NCSs) is reported. This remote C(sp3)-H functionalization can be achieved in weak basic solution at room temperature with as little as 0.1 mol % of
