26452-98-2Relevant articles and documents
Investigations into the C-deuteriation of enol acetates derived from aryl alkyl ketones
Buksha, Svitlana,Coumbarides, Gregory S.,Dingjan, Marco,Eames, Jason,Suggate, Michael J.,Weerasooriya, Neluka
, p. 337 - 352 (2005)
Results are reported on the regioselective C-deuteriation of a series of enol acetates (derived from the aryl alkyl ketones) using molecular deuterium as the D-source and palladium-on-barium sulphate as the mediator. The results presented highlight potent
DMAP-based flexible polymer networks formed via Heck coupling as efficient heterogeneous organocatalysts
Xu, Wei,Xia, Wu,Guan, Yukun,Wang, Yiming,Lu, Cuifen,Yang, Guichun,Nie, Junqi,Chen, Zuxing
, p. 15 - 21 (2016/06/14)
Two DMAP-based flexible polymer networks TPB-DMAP and TPA-DMAP have been successfully synthesized via palladium catalyzed Heck cross-coupling. The structures of these polymers were confirmed by solid state 13C CP/MAS and Fourier transform infrared spectroscopy (FTIR). Although both polymers have negligible surface areas, they exhibit excellent catalytic efficiency for the acylation of 1-phenylethanol with acetic anhydride due to their good swelling capacities. Utilized as a typical catalyst, the polymer TPA-DMAP shows high activities for acylation of a variety of alcohols to the corresponding esters. Moreover, the catalyst can be recycled at least ten times without obvious loss of catalytic activity.
Chemoenzymatic synthesis of rasagiline mesylate using lipases
De Mattos, Marcos Carlos,De Fonseca, Thiago Sousa,Da Silva, Marcos Reinaldo,De Oliveira, Maria Da Concei??o Ferreira,De Lemos, Telma Leda Gomes,De Marques, Ricardo Araújo
, p. 76 - 82 (2015/05/04)
A straightforward chemoenzymatic synthesis of rasagiline mesylate has been developed. The key steps for the introduction of chirality involved kinetic enzymatic resolution with lipases via acetylation of racindanol and an inversion configuration Mitsunobu reaction of the produced (S)-indanol. Immobilized lipase from Thermomyces lanuginosus proved to be a robust biocatalyst in the kinetic resolution, leading to (S)-indanol with high selectivity (e.e. > 99%, E > 200) in just 15 min, at 35°C, in hexane, being reused for ten-times without significant loss of the activity and selectivity.
