2568-65-2

Basic information

• Product Name: 3-Phenyl-2-propynyldimethylamine
• Synonyms: 1-Phenyl-3-(dimethylamino)-1-propyne;3-Phenyl-2-propynyldimethylamine;N,N-Dimethyl-1-phenyl-1-propyne-3-amine;N,N-Dimethyl-3-phenyl-2-propyn-1-amine;N,N-Dimethyl-3-phenylpropargylamine
• CAS NO: 2568-65-2
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.23
• Mol File: 2568-65-2.mol
• Article Data: 34

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Phenyl-2-propynyldimethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-2-propynyldimethylamine(2568-65-2)
• EPA Substance Registry System: 3-Phenyl-2-propynyldimethylamine(2568-65-2)

Safety Data

• Hazardous Substances Data: 2568-65-2(Hazardous Substances Data)

Upstream product

• 38846-08-1 4,4-dimethyl-3-dimethylamino-1-phenylhex-5-en-1-yne 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 536-74-3 phenylacetylene 
• 56275-84-4 N-(butoxymethyl)dimethylamine 
• 75-50-3 trimethylamine 
• 3355-31-5 1-chloro-3-phenyl-2-propyne 
• 124-40-3 dimethyl amine 
• 51-80-9 bis-(dimethylamino)methane 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 7223-38-3 N,N-Dimethylpropargylamin 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 42900-95-8 4-[(dimethylamino)methyl]-2,6-dimethylphenol 

Downstream Products

• 1199-99-1 N,N-dimethyl-3-phenylpropylamine 
• 75712-94-6 (Z)-N,N-dimethyl-3-phenylprop-2-en-1-amine 
• 111119-60-9 1-Phenyl-1,2-trans-dibromo-3-dimethylamino-1-propene 
• 3506-36-3 3-dimethylaminopropiophenone 
• 86969-86-0 2-butyl-N,N-dimethyl-3-phenyl-2-propen-1-amine 
• 75377-15-0 cis-but-2-enyldimethyl-(3-phenylprop-2-ynyl)ammonium bromide 
• 75377-02-5 trans-but-2-enyldimethyl-(3-phenylprop-2-ynyl)ammonium bromide 
• 79841-43-3 (9-fluorenyl)dimethyl-(3-phenylprop-2-ynyl)ammonium bromide 
• 38846-04-7 dimethyl-(2-phenylallyl)-(3-phenylprop-2-ynyl)ammonium bromide 
• 85972-84-5 N,N-dimethylamino-3 phenyl-1 cyclohexyl-2 propene-1 
• 85972-83-4 N,N-dimethylamino-3 phenyl-1 cyclohexyl-1 propene-1 
• 76084-59-8 dimethyl-<(2E)-2-methylpenta-2,4-dienyl>-(3-phenylprop-2-ynyl)ammonium bromide 
• 75954-84-6 dimethyl-<(2E)-4-methylpenta-2,4-dienyl>-(3-phenylprop-2-ynyl)ammonium bromide 
• 75376-93-1 (αα-dideuteriocinnamyl)dimethyl-(3-phenylprop-2-ynyl)ammonium bromide 

Relevant articles and documents

N,N,N′,N′-tetramethylmethanediamine - A new reagent for aminomethylation of acetylenes

A new procedure has been developed for aminomethylation of terminal acetylenes with N,N,N′,N′-tetramethylmethanediamine in the presence of transition metals and lanthanide complexes and salts. The procedure ensures formation of the corresponding N,N-dimethylprop-2-yn-1-amines with high yield and selectivity.

Synthesis and Application of Silylene-Stabilized Low-Coordinate Ag(I)-Arene Cationic Complexes

We report the first examples of N-heterocyclic silylene-stabilized monocoordinate Ag(I) cationic complexes weakly bound to the free arene rings (C6H6, C6Me6, and C7H8). Further, the application of these electrophilic Ag(I) complexes as catalysts has been investigated toward A3-coupling reactions, which afforded a series of propargylamines in good to excellent yields with low catalyst loading under a solvent-free condition (19 examples).

Fast heck-cassar-sonogashira (hcs) reactions in green solvents

The replacement of toxic solvents with greener alternatives in Heck-Cassar-Sonogashira (HCS) cross-couplings was investigated. The fine-tuning of the HCS protocol allowed to achieve complete conversions and high speed under mild conditions. N-Hydroxyethylpyrrolidone (HEP) gave the best results. Moreover, the methodology was successfully applied to the synthesis of an intermediate of the anticancer drug Erlotinib, demonstrating the versatility of the new green protocol.

Practical synthesis of silyl-protected and functionalized propargylamines using nanostructured Ag/TiO2 and Pt/TiO2 as active recyclable catalysts

Abstract: Herein we report the use of Ag/TiO2 and Pt/TiO2 nanocatalysts to promote the synthesis of a series of silyl-protected and functionalized propargylamine derivatives through alkyne–amine–aldehyde (A3) coupling unde