2570-43-6

Basic information

• Product Name: 3,4-DIMETHOXYTHIOANISOLE
• Synonyms: 3,4-DIMETHOXYTHIOANISOLE
• CAS NO: 2570-43-6
• Molecular Formula: C₉H₁₂O₂S
• Molecular Weight: 184.26
• Mol File: 2570-43-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-DIMETHOXYTHIOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXYTHIOANISOLE(2570-43-6)
• EPA Substance Registry System: 3,4-DIMETHOXYTHIOANISOLE(2570-43-6)

Safety Data

• Hazardous Substances Data: 2570-43-6(Hazardous Substances Data)

Usage

General Description

3,4-DIMETHOXYTHIOANISOLE is a chemical compound with the molecular formula C9H12O3S. It is a clear to pale yellow liquid with a strong, sweet, and sulfurous odor. This chemical is commonly used as a flavoring agent in the food industry and also as a fragrance in the perfume and cosmetic industries. Its unique scent is often described as sweet, creamy, and slightly floral. Additionally, 3,4-DIMETHOXYTHIOANISOLE has been studied for its potential anti-inflammatory and antioxidant properties, making it a potential candidate for pharmaceutical and skincare applications. However, it is important to handle and use this chemical with care, as it can cause irritation to the skin, eyes, and respiratory system if not properly handled.

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Relevant articles and documents

A Mononuclear Non-Heme Manganese(III)-Aqua Complex in Oxygen Atom Transfer Reactions via Electron Transfer

Metal-oxygen complexes, such as metal-oxo [M(O2-)], -hydroxo [M(OH-)], -peroxo [M(O22-)], -hydroperoxo [M(OOH-)], and -superoxo [M(O2?-)] species, are capable of conducting oxygen atom transfer (OAT) reactions with organic substrates, such as thioanisole (PhSMe) and triphenylphosphine (Ph3P). However, OAT of metal-aqua complexes, [M(OH2)]n+, has yet to be reported. We report herein OAT of a mononuclear non-heme Mn(III)-aqua complex, [(dpaq)MnIII(OH2)]2+ (1, dpaq = 2-[bis(pyridin-2-ylmethyl)]amino-N-quinolin-8-yl-acetamidate), to PhSMe and Ph3P derivatives for the first time; it is noted that no OAT occurs from the corresponding Mn(III)-hydroxo complex, [(dpaq)MnIII(OH)]+ (2), to the substrates. Mechanistic studies reveal that OAT reaction of 1 occurs via electron transfer from 4-methoxythioanisole to 1 to produce the 4-methoxythioanisole radical cation and [(dpaq)MnII(OH2)]+, followed by nucleophilic attack of H2O in [(dpaq)MnII(OH2)]+ to the 4-methoxythioanisole radical cation to produce an OH adduct radical, 2,4-(MeO)2C6H3S?(OH)Me, which disproportionates or undergoes electron transfer to 1 to yield methyl 4-methoxyphenyl sulfoxide. Formation of the thioanisole radical cation derivatives is detected by the stopped-flow transient absorption measurements in OAT from 1 to 2,4-dimethoxythioanisole and 3,4-dimethoxythioanisole, being compared with that in the photoinduced electron transfer oxidation of PhSMe derivatives, which are detected by laser-induced transient absorption measurements. Similarly, OAT from 1 to Ph3P occurs via electron transfer from Ph3P to 1, and the proton effect on the reaction rate has been discussed. The rate constants of electron transfer from electron donors, including PhSMe and Ph3P derivatives, to 1 are fitted well by the electron transfer driving force dependence of the rate constants predicted by the Marcus theory of outer-sphere electron transfer.

Reduction of CO2 with NaBH4/I2 for the Conversion of Thiophenols to Aryl Methyl Sulfides

We report a tandem reaction to realize reduction of carbon dioxide with thiophenols to generate aryl methyl sulfides under the NaBH4/I2 system with 18-crown-6 as the solvent. Thiophenols bearing electron-donating and electron-withdrawing groups are feasible in this reaction. Controlled experiment results indicate that 18-crown-6 plays a critical role in six-electron reduction of carbon dioxide.

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5- trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric com