2812-47-7

Basic information

• Product Name: H-DL-PRO-NH2
• Synonyms: PYRROLIDINE-2-CARBOXAMIDE;H-DL-PRO-NH2;IFLAB-BB F2124-0727;2-PYRROLIDINECARBOXAMIDE
• CAS NO: 2812-47-7
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.15
• Product Categories: Amino Acids Derivatives;Proline [Pro, P];Aromatics;Catalyst;Heterocycles
• Mol File: 2812-47-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 303.6±31.0 °C(Predicted)
• Appearance: /
• Density: 1.106
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 16.21±0.20(Predicted)
• CAS DataBase Reference: H-DL-PRO-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-DL-PRO-NH2(2812-47-7)
• EPA Substance Registry System: H-DL-PRO-NH2(2812-47-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41-51
• Safety Statements: 26-39
• Hazardous Substances Data: 2812-47-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2812-47-7 differently. You can refer to the following data:
1. H-DL-PRO-NH2 is a proline derivative used in DNA catalysts for the aldol reaction between a porphyrin-bearing aldehyde and a ketone.
2. A proline derivative used in DNA catalysts for the aldol reaction between a porphyrin-bearing aldehyde and a ketone.

Upstream product

• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 
• 1148-11-4 N-carbobenzyloxyproline 
• 93188-01-3 2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 57015-08-4 pyrrolidine-2-carbonitrile 
• 5626-64-2 DL-Pro-NCA 
• 60169-67-7 ethyl pyrrolidine-2-carboxylate 

Downstream Products

• 30130-35-9 N-acetylprolinamide 
• 93188-01-3 2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 62937-47-7 (2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 57734-44-8 1-benzyl-2-aminomethyl-pyrrolidine 
• 60169-70-2 1-benzylpyrrolidine-2-carboxamide 
• 25746-83-2 (±)-N-phenylpyrrolidine-2-carboxamide 
• 63155-83-9 L-pyroglutamyl-L-prolinamide 
• 364789-40-2 (2 R)-1-{4-[3-cyano-4-(2,4-dichloro-5-methoxyanilino)-7-quinolinyl]benzyl }-2-pyrrolidinecarboxamide 
• 697802-31-6 C₂₀H₃₄N₄O₆ 
• 23500-10-9 (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid 
• 68-95-1 (S)-acetylproline 
• 57734-57-3 2-amino-methylpyrrolidine 
• 32159-20-9 L-His(CH₂Ph)-L-Pro-NH₂*2HBr 
• 151378-30-2 Tfa-Pro-NH2 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION

The present invention provides novel compounds having general formula (I), wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.

Catalytic epoxidation of unfunctionalized alkenes by dinuclear nickel(II) complexes

The synthesis, crystal and molecular structure and catalytic activity in epoxidation reactions of new dinuclear nickel(II)-complexes, octahedral μ-diacetato-μ-[2,6-bis[N-2-2'-pyridylethyl)formimidoyl]phenolato]bis nickel(II)·perchlorate·methanol (6) and square planar (μ-hydroxo-μ-[2,6-bis[N-((S)-1-benzyl-2-yl-pyrrolidine)formimidoyl]p henolato]bisnickel(II)·bisperchlorate (7), are described. For the preparation of 7 a new 5-step route for homochiral bisamine (S)-benzyl-2-aminomethyl-pyrrolidine (19) was developed starting from (S)-proline. Epoxidation of unfunctionalized alkenes with sodium hypochlorite and tert-butyl hydroperoxide as terminal oxidants was effectively catalyzed with bisnickel(II)-complexes 6 and 7, and a turnover of 165 was reached using trans-β-methylstyrene (34). The epoxidations probably proceed via a radical intermediate (such as OCl·) and no enantioselectivity is obtained under phase transfer conditions. In epoxidation reactions employing tert-butyl hydroperoxide as terminal oxidant a turnover of 43 was obtained with trans-stilbene (30) as substrate. Unexpectedly in the case of styrene (29) 1,2-bis-(tert-butylperoxy)ethylbenzene (59) was isolated as the major product.

OXYDATION OF SECONDARY AMINES TO α-CYANOAMINES

The dehydrogenation of secondary amines with phenylseleninic anhydride or acid under mild conditions in the presence of either sodium cyanide or trimethylsilylcyanide gives good yields of α-cyanoamines.These compounds can be regarded as protected imines, or as a source of α-amino-acids.