2812-47-7

Usage

Uses

Used in DNA Catalysts:
H-DL-PRO-NH2 is used as a component in DNA catalysts for the aldol reaction between a porphyrin-bearing aldehyde and a ketone. This application is particularly relevant in the field of synthetic chemistry, where the compound contributes to the development of novel and efficient catalysts for complex chemical reactions.
Used in Chemical Synthesis:
In the Chemical Synthesis industry, H-DL-PRO-NH2 is used as a proline derivative for the aldol reaction between a porphyrin-bearing aldehyde and a ketone. This reaction is crucial for the synthesis of various complex organic molecules, including those with potential applications in pharmaceuticals, materials science, and other areas.

Upstream product

• 60169-67-7 ethyl pyrrolidine-2-carboxylate 
• 5626-64-2 DL-Pro-NCA 
• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 
• 93188-01-3 2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 57015-08-4 pyrrolidine-2-carbonitrile 
• 1148-11-4 N-carbobenzyloxyproline 

Downstream Products

• 30130-35-9 N-acetylprolinamide 
• 93188-01-3 2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 62937-47-7 (2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 117368-39-5 Tfa-DL-Pro-NH2 
• 60169-70-2 1-benzylpyrrolidine-2-carboxamide 
• 147-85-3 L-proline 
• 226249-98-5 2-carbamoyl-1-(4-chlorobenzyl)pyrrolidine 
• 60737-12-4 C-[1-(4-chloro-benzyl)-pyrrolidin-2-yl]-methylamine 
• 57734-44-8 1-benzyl-2-aminomethyl-pyrrolidine 
• 117368-39-5 Tfa-D-Pro-NH2 
• 151378-30-2 Tfa-Pro-NH2 
• 57734-57-3 2-amino-methylpyrrolidine 
• 68-95-1 (S)-acetylproline 
• 23500-10-9 (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION

The present invention provides novel compounds having general formula (I), wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

Catalytic epoxidation of unfunctionalized alkenes by dinuclear nickel(II) complexes

The synthesis, crystal and molecular structure and catalytic activity in epoxidation reactions of new dinuclear nickel(II)-complexes, octahedral μ-diacetato-μ-[2,6-bis[N-2-2'-pyridylethyl)formimidoyl]phenolato]bis nickel(II)·perchlorate·methanol (6) and square planar (μ-hydroxo-μ-[2,6-bis[N-((S)-1-benzyl-2-yl-pyrrolidine)formimidoyl]p henolato]bisnickel(II)·bisperchlorate (7), are described. For the preparation of 7 a new 5-step route for homochiral bisamine (S)-benzyl-2-aminomethyl-pyrrolidine (19) was developed starting from (S)-proline. Epoxidation of unfunctionalized alkenes with sodium hypochlorite and tert-butyl hydroperoxide as terminal oxidants was effectively catalyzed with bisnickel(II)-complexes 6 and 7, and a turnover of 165 was reached using trans-β-methylstyrene (34). The epoxidations probably proceed via a radical intermediate (such as OCl·) and no enantioselectivity is obtained under phase transfer conditions. In epoxidation reactions employing tert-butyl hydroperoxide as terminal oxidant a turnover of 43 was obtained with trans-stilbene (30) as substrate. Unexpectedly in the case of styrene (29) 1,2-bis-(tert-butylperoxy)ethylbenzene (59) was isolated as the major product.

ENANTIOMERIC QUANTIFICATIONS OF AMINO ACIDS THROUGH THEIR Nα-ACYL AMIDES BY GAS CHROMATOGRAPHY.

Apparent separation of 1.1 or higher on Chirasil Val III can be obtained for Nα-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns.A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from "in situ" silylated amino acids with trimethylsilyl cyanide.

OXYDATION OF SECONDARY AMINES TO α-CYANOAMINES

The dehydrogenation of secondary amines with phenylseleninic anhydride or acid under mild conditions in the presence of either sodium cyanide or trimethylsilylcyanide gives good yields of α-cyanoamines.These compounds can be regarded as protected imines, or as a source of α-amino-acids.

Formation of By-products during Sodium-Liquid Ammonia Reduction in Peptide Chemistry

Reduction of protected model peptides by the usual excess of sodium in liquid ammonia leads to undesired by-products; the generally accepted blue colour for the end point is unnecessary for complete reduction.

Method for making aminoacid amides

The present process describes a new and improved method for making the amides of an aminoacid. The new procedure involves only two steps, produces good yield and requires neither isolation nor purification of the intermediate. It also assures that the optical rotation of the starting material is not affected.