257938-64-0Relevant articles and documents
Process and intermediates for preparation of substituted piperidines
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, (2008/06/13)
The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof comprising a) hydroboration of a compound of formula 2 A, R1and R2are as herein defined. These comp
Piperidine renin inhibitors: from leads to drug candidates
Maerki, H. P.,Binggeli, A.,Bittner, B.,Bohner-Lang, V.,Breu, V.,Bur, D.,Coassolo, Ph.,Clozel, J. P.,D'Arcy, A.,Doebeli, H.,Fischli, W.,et al.
, p. 21 - 28 (2007/10/03)
Non-peptidomimetic renin inhibitors of the piperidine type represent a novel structural class of compounds potentially free of the drawbacks seen with peptidomimetic compounds so far. Synthetic optimization in two structural series focusing on improvement