257938-64-0

Upstream product

• 80-56-8 Pinene 
• 28875-08-3 monoisopinocampheylborane 
• 75-07-0 acetaldehyde 
• 257928-43-1 (R)-4-(4-benzyloxy-phenyl)-1-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine 
• 16940-66-2 sodium tetrahydroborate 

Downstream Products

• 783291-76-9 (3R,4R)-4-(4-Hydroxy-phenyl)-piperidin-3-ol 
• 257938-67-3 tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate 
• 257938-68-4 (3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 257938-72-0 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(quinolin-7-yl-methoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 257938-73-1 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 304025-53-4 Ro 661168 
• 304025-82-9 (3R,4R)-3-[1-(2-acetylamino-ethyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Process and intermediates for preparation of substituted piperidines

The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof comprising a) hydroboration of a compound of formula 2 A, R1and R2are as herein defined. These comp

Piperidine renin inhibitors: from leads to drug candidates

Non-peptidomimetic renin inhibitors of the piperidine type represent a novel structural class of compounds potentially free of the drawbacks seen with peptidomimetic compounds so far. Synthetic optimization in two structural series focusing on improvement