257938-68-4

Upstream product

• 257938-67-3 tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate 
• 257938-64-0 (3R,4R)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol 
• 257928-43-1 (R)-4-(4-benzyloxy-phenyl)-1-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine 
• 783291-76-9 (3R,4R)-4-(4-Hydroxy-phenyl)-piperidin-3-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 188875-36-7 1-(3-Chloro-propoxymethyl)-2-methoxy-benzene 

Downstream Products

• 257938-72-0 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(quinolin-7-yl-methoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 857273-38-2 tert-butyl (3R,4R)-3-(1(S)-ethoxycarbonylethoxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate 
• 257938-69-5 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-[7-(2-trimethylsilanyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylic acid tert-butylester 
• 304025-82-9 (3R,4R)-3-[1-(2-acetylamino-ethyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 304025-53-4 Ro 661168 
• 257938-73-1 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Piperidine derivatives

Compounds of formula (I) wherein R1and R2are as defined in the description and claims and pharmaceutically acceptable salts thereof, are useful for the treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, for example, cardiac insufficiency and kidney insufficiency.

Piperidine renin inhibitors: from leads to drug candidates

Non-peptidomimetic renin inhibitors of the piperidine type represent a novel structural class of compounds potentially free of the drawbacks seen with peptidomimetic compounds so far. Synthetic optimization in two structural series focusing on improvement