304025-53-4Relevant articles and documents
Piperidine renin inhibitors: from leads to drug candidates
Maerki, H. P.,Binggeli, A.,Bittner, B.,Bohner-Lang, V.,Breu, V.,Bur, D.,Coassolo, Ph.,Clozel, J. P.,D'Arcy, A.,Doebeli, H.,Fischli, W.,et al.
, p. 21 - 28 (2001)
Non-peptidomimetic renin inhibitors of the piperidine type represent a novel structural class of compounds potentially free of the drawbacks seen with peptidomimetic compounds so far. Synthetic optimization in two structural series focusing on improvement