64214-66-0

Basic information

• Product Name: 4-Chloro-N-Methoxy-N-MethylbutyraMide
• Synonyms: 4-Chloro-N-Methoxy-N-MethylbutyraMide;4-Chloro-N-methoxy-N-methylbutanamide
• CAS NO: 64214-66-0
• Molecular Formula: C₆H₁₂ClNO₂
• Molecular Weight: 165.61798
• EINECS: -0
• Mol File: 64214-66-0.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 199.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.106±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chloro-N-Methoxy-N-MethylbutyraMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-N-Methoxy-N-MethylbutyraMide(64214-66-0)
• EPA Substance Registry System: 4-Chloro-N-Methoxy-N-MethylbutyraMide(64214-66-0)

Safety Data

• Hazardous Substances Data: 64214-66-0(Hazardous Substances Data)

Usage

General Description

4-Chloro-N-Methoxy-N-MethylbutyraMide is a chemical compound with the molecular formula C6H12ClNO2. It is a white crystalline powder with a molecular weight of 169.62 g/mol. 4-Chloro-N-Methoxy-N-MethylbutyraMide is also known by its CAS number 1603-41-4. It is commonly used as a pharmaceutical intermediate, particularly in the synthesis of various drugs. Its properties and structure make it a valuable building block in medicinal chemistry and drug discovery. However, it is important to handle this chemical with care, as it may pose health hazards if mishandled or improperly used, such as skin and eye irritation.

Upstream product

• 3153-36-4 4-chloro-butyric acid ethyl ester 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 3153-37-5 methyl 4-chlorobutyrate 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 7623-11-2 2-chlorobutyryl chloride 

Downstream Products

• 5891-21-4 5-chloro-2-pentanone 
• 1246385-18-1 C₁₇H₁₄ClFN₂O 
• 38425-26-2 4-chloro-1-(4-methylphenyl)butan-1-one 
• 80086-24-4 6-chloro-1-phenylhexan-3-one 
• 1216260-42-2 4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one 
• 40877-19-8 4-chloro-1-(4-methoxyphenyl)butan-1-one 
• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 40877-17-6 4-chloro-1-(2-methoxyphenyl)-1-butanone 
• 43076-59-1 4-chloro-1-(thien-2-yl)-1-butanone 
• 258882-48-3 4-chloro-1-(3-methoxyphenyl)-1-butanone 
• 150668-36-3 4-chloro-1-(3,5-dimethylphenyl)butan-1-one 
• 138344-14-6 [2-(5-Chloro-2-oxo-pentyl)-4-methoxy-phenyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Development of a tandem cyclization mediated by samarium(II) iodide: sequential intramolecular conjugate addition/nucleophilic acyl substitution

The development of a one-pot tandem intramolecular conjugate addition/nucleophilic acyl substitution using samarium(II) iodide is reported. The reaction relies on the reagent's unique ability to mediate both radical and anionic pathways, which are likely integral to the mechanism of this transformation. The tricyclic hemiacetal product was formed in good yield, with excellent diastereoselectivity, and its structure was verified by X-ray crystallographic analysis.

Pyrazolopyrimidine macrocyclic derivative and application thereof

The invention relates to a novel pyrazolopyrimidine macrocyclic derivative as well as a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrazolopyrimidine macrocyclic derivative as shown in a general formula (I), a preparation method thereof, and application of the pyrazolopyrimidine macrocyclic derivative or a pharmaceutical composition containing the derivative as a therapeutic agent, especially as a tropomyosin-related kinase (TRK) inhibitor, in treatment or prevention of TRK-mediated related diseases such as tumors. Substituents (R1, R2) and groups (X) in the general formula (I) are as defined in the description.

AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR

Provided is an amino pyrazolopyrimidine compound as represented by the following structural formula used as a neurotrophic factor tyrosine kinase receptor inhibitor. The compound can inhibit the activity of Trk kinase and can treat diseases mediated by a Trk tyrosine kinase receptor in mammals.