25907-32-8Relevant academic research and scientific papers
Pd-Catalyzed Triple-Fold C(sp2)-H Activation with Enaminones and Alkenes for Pyrrole Synthesis via Hydrogen Evolution
Fu, Leiqing,Liu, Yunyun,Wan, Jie-Ping
, p. 4363 - 4367 (2021)
The synthesis of NH-free pyrroles via Pd-catalyzed annulation of enaminones and alkenes is reported. With the catalysis of Pd(II), the activation of triple C(sp2)-H bonds, including one internal C(sp2)-H bond in enaminone, has been activated to provide various pyrroles. The interesting evolution of hydrogen gas from the reactions has been observed by a hydrogen detector.
Direct synthesis of 2,3,5-trisubstituted pyrroles: via copper-mediated one-pot multicomponent reaction
He, Jian-Ping,Huang, Guo-Sheng,Luo, Nan,Zhan, Zhen-Zhen,Zhang, Ming-Ming
, p. 9831 - 9835 (2021/01/05)
We have developed a copper-mediated one-pot synthesis of 2,3,5-trisubstituted pyrroles from 1,3-dicarbonyl compounds and acrylates using ammonium acetate as a nitrogen source. The reaction achieves C-C and C-N bond formation and provides an efficient approach to access highly functionalized pyrroles without further raw material preparation. This method is operationally simple, compatible with a wide range of functional groups, and provides the target products in moderate to good yields. This journal is
PYRROLE COMPOUND
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Paragraph 0547; 0669; 0670; 0671, (2014/12/09)
Provided is a highly safe and effective compound represented by the following general formula (1) or a salt thereof which acts on tubulin and has an anticancer effect, wherein Ar represents an aryl group or a heteroaryl group; Z1, Z2
