89315-56-0

Basic information

• Product Name: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline;Isoquinoline,5,7-dichloro-1,2,3,4-tetrahydro-
• CAS NO: 89315-56-0
• Molecular Formula: C₉H₉Cl₂N
• Molecular Weight: 202.08046
• EINECS: -0
• Mol File: 89315-56-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 308.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.28±0.20(Predicted)
• CAS DataBase Reference: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline(89315-56-0)
• EPA Substance Registry System: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline(89315-56-0)

Safety Data

• Hazardous Substances Data: 89315-56-0(Hazardous Substances Data)

Usage

General Description

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline is a chemical compound that belongs to the class of tetrahydroisoquinolines, which are a group of organic compounds with a bicyclic structure containing a tetrahydroisoquinoline core. This specific compound contains two chlorine atoms on the 5th and 7th positions of the tetrahydroisoquinoline ring. It is used in organic synthesis and pharmaceutical research as a building block for the development of various compounds with potential biological activities. The presence of chlorine atoms makes it a valuable intermediate in the synthesis of other organic compounds, and its unique structure makes it a target of interest in medicinal chemistry for the development of new drugs. Additionally, it may also have potential applications in the field of materials science and chemical engineering. Overall, the 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline is a versatile chemical with diverse potential applications in various scientific and industrial fields.

Upstream product

• 1346177-18-1 C₉H₇Cl₂N 
• 6306-60-1 2,4-Dichlorophenylacetonitrile 
• 259796-12-8 3,5-dichloro-N-methoxy-N-methylbenzamide 
• 51-36-5 3,5-dichlorobenzoic acid 
• 52516-13-9 2-(2,4-dichloro-phenyl)-ethylamine 
• 34209-97-7 2,4-dichloro-1-(2-nitrovinyl)benzene 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 14046-52-7 N-(2-chloroethyl)-3,5-dichlorobenzylamine hydrochloride 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 73075-58-8 5,7-dichloro isoquinoline 

Downstream Products

• 1289646-93-0 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride 
• 851784-82-2 2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1194550-65-6 benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride 
• 1194550-63-4 C₄₆H₄₀Cl₂N₂O₅S 
• 1194550-56-5 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 1289646-72-5 C₂₈H₂₃Cl₂N 

Relevant articles and documents

Preparation method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline

The invention provides a preparation method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline. The preparation method comprises the following steps: preparing a compound A by taking 3, 5-dichlorobenzoic acid as a raw material; preparing a compound B from the compound A; preparing a compound C from the compound B; preparing a compound D from the compound C; and obtaining a white solid 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline from the compound D. The preparation method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline provided by the invention has the advantages of high product purity and high product yield.

Synthesis method of lifitegrast intermediate 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline

The invention discloses a synthesis method of a lifitegrast intermediate 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline, wherein the synthesis method comprises the steps: by using 2,4-dichlorobenzaldehyde as a starting material, carrying out nitro-alcohol co

Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eye

LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte extravasation, migration, antigen presentation, formation of immunological synapse, and augmentation of T-cell receptor signaling. The increase of ICAM-1 expression levels in conjunctival epithelial cells and acinar cells was observed in animal models and patients diagnosed with dry eye. Therefore, it has been hypothesized that small molecule LFA-1/ICAM-1 antagonists could be an effective topical treatment for dry eye. In this letter, we describe the discovery of a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist (SAR 1118) and its development as an ophthalmic solution for treating dry eye.