25988-32-3

Upstream product

• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 19995-85-8 4-chloro-3-methyl-butan-2-one 
• 20963-51-3 3-methylbut-3-en-2-one oxime 
• 3393-64-4 4-hydroxy-3-methyl-2-butanone 
• 22104-62-7 4-dimethylamino-3-methylbutan-2-one 
• 71339-40-7 3-methyl-4-oxo-pent-2-enoic acid 
• 10235-71-9 3-Acetoxy-3-methyl-2-butanon 
• 920-39-8 isopropylmagnesium bromide 
• 108-24-7 acetic anhydride 
• 104-15-4 toluene-4-sulfonic acid 
• 64-19-7 acetic acid 
• 78-80-8 2-methylbut-1-en-3-yne 
• 463-51-4 Ketene 
• 431-03-8 dimethylglyoxal 

Downstream Products

• 14539-67-4 4-methoxy-3-methyl-butan-2-one 
• 89794-79-6 3-hydroxymethyl-4-methoxy-3-methyl-butan-2-one 
• 408338-20-5 3-methyl-4-propoxy-butan-2-one 
• 101170-10-9 4-ethyl-4-butyl-6-methyl-cyclohex-2-enone 
• 35504-34-8 2,3-dimethyl-pent-1-en-4-yn-3-ol 
• 82262-31-5 4,6-dimethyl-1,3-cyclohexanedione 
• 4587-00-2 2-acetyl-2-methyloxirane 
• 18229-58-8 1-(2,5,6-trimethyl-3,4-dihydro-2H-pyran-2-yl)-ethanone 
• 89487-71-8 3,4-dichloro-3-methyl-butan-2-one 
• 993-70-4 3,4-dihydroxy-3-methyl-butan-2-one 
• 2568-73-2 (+/-)-1-Acetyl-2,2-dibrom-1-methyl-cyclopropan 
• 33334-69-9 1-(1-Methyl-2-methylene-cyclohex-3-enyl)-ethanone 
• 33321-99-2 1-(1-Methyl-5-methylene-cyclohex-3-enyl)-ethanone 
• 40618-71-1 4,5-dimethyl-2-phenyl-2,3-dihydro-[1,2]oxaphosphole 2-sulfide 

Relevant academic research and scientific papers

Reactions of a tungsten-germylyne complex with α,β-unsaturated ketones: Complete cleavage of the W/Ge bond and formation of two types of η3-germoxyallyl tungsten complexes

Germylyne complex Cp(CO)2W/Ge{C(SiMe3)3} (1) reacted with two molecules of RC(O)CH=CH2 (R = Me, Et) to give η3-allyl complexes, in which an oxagermacyclopentene framework was bound to an η3-allyl ligand through an oxygen atom. In the reaction with α-Me-substituted MeC(O)C(Me)=CH2, 1 reacted with only one molecule of the substrate to give another type of η3- allyl complex, in which a five-membered oxagermacyclopentenyl ring was coordinated to the W center in an η3 fashion. Both reactions resulted in unprecedented complete cleavage of a W/Ge triple bond.

Reactions of methylaluminium compounds with methacrylonitrile

Reactions of trimethylaluminium, dimethylaluminium chloride and methylaluminium dichloride with methacrylonitrile have been investigated. These reactions afford corresponding donor-acceptor complexes. At elevated temperatures they react to yield methyl is

Kinetics of the Unimolecular Elimination of Chlorobutanones in the Gas Phase

The gas-phase unimolecular elimination of 3-chloro-3-methyl-2-butanone has been investigated, in a static system and seasoned vessel, over the temperature range of 340-395 deg C and the pressure range of 60-190 torr.The reaction is homogeneous and unimolecular, follows a first-order rate law, and is invariable in the presence of cyclohexane, a radical-chain inhibitor.The products are isopropenyl methyl ketone and hydrogen chloride.The rate coefficients are given by the Arrhenius equation log k1 (s-1) = (12.56+/-0.31)-(190.8+/-3.7) kJ mol-1 (2.303RT)-1.When primary, secondary, and tertiary chlorobutanones are compared the presence of acetyl at the Cβ-Cl bond causes a significant rate enhancement due to the -M effect.However, if this substituent is at the Cα-Cl bond , deactivation in rate of elimination of these compounds is observed.The present work could well provide a general view on the effect of the acetyl substituent at the Cα-Cl and Cβ-Cl bonds in the molecular elimination of haloketones in the gas phase.

Cassis and Green Tea: Spontaneous Release of Natural Aroma Compounds from β-Alkylthioalkanones

In depth headspace analysis of the slow degradation of β-alkylthioalkanones in ambient air led to the discovery of a novel δ-cleavage pathway, by which β-mercaptoketones are released. Since β-mercaptoketones are potent natural aroma compounds occurring in many fruits, herbs and flowers, the discovery of an enzyme-independent molecular precursor for this class of high-impact molecules is of practical importance. Moreover, the formation of β-diketones and aldehydes by concomitant oxidation at the α-sulfur-position enhances the versatility of this class of aroma precursors. A mechanistic model is proposed which suggests that the oxidative degradation occurs through a novel Pummerer-type rearrangement of initially formed persulfoxides.

Ketone Formation from Carboxylic Acids by Ketonic Decarboxylation: The Exceptional Case of the Tertiary Carboxylic Acids

For the reaction mechanism of the ketonic decarboxylation of two carboxylic acids, a β-keto acid is favored as key intermediate in many experimental and theoretical studies. Hydrogen atoms in the α-position are an indispensable requirement for the substrates to react by following this mechanism. However, isolated observations with tertiary carboxylic acids are not consistent with it and these are revisited and discussed herein. The experimental results obtained with pivalic acid indicate that the ketonic decarboxylation does not occur with this substrate. Instead, it is consumed in alternative reactions such as disintegration into isobutene, carbon monoxide, and water (retro-Koch reaction). In addition, the carboxylic acid is isomerized or loses carbon atoms, which converts the tertiary carboxylic acid into carboxylic acids bearing α-proton atoms. Hence, the latter are suitable to react through the β-keto acid pathway. A second substrate, 2,2,5,5-tetramethyladipic acid, reacted by following the same retro-Koch pathway. The primary product was the monocarboxylic acid 2,2,5-trimethyl-4-hexenoic acid (and its double bond isomer), which might be further transformed into a cyclic enone or a lactone. The ketonic decarboxylation product, 2,2,5,5-tetramethylcyclopentanone was observed in traces (0.2 % yield). Therefore, it can be concluded that the observed experimental results further support the proposed mechanism for the ketonic decarboxylation via the β-keto acid intermediate.

A structure/catalytic activity study of gold(i)-NHC complexes, as well as their recyclability and reusability, in the hydration of alkynes in aqueous medium

We conducted a structure/catalytic activity study of water-soluble gold(i) complexes-supporting sulfonated NHC ligands-in the hydration of alkynes in pure water or water nsp;:nsp;methanol (1nsp;:nsp;1), as well as their recyclability. Comparative studies were carried out with the addition of different silver salts. Our results indicate that the bulkier complex is the most effective and that the addition of methanol as co-solvent not only shortens reaction times but also stabilizes the less bulky complexes.

Hydroxyketones in the thiadiazine cycle formation

Cyclocondensation of 1-hydroxyketones with thiosemicarbazide resulted in thiadiazines. Nitrate ester of 1-hydroxyketone reacted under similar conditions to give the corresponding thiosemicarbazone. In the case of bromoacetyl-substituted nitrate ester of 1-hydroxyketone, condensation proceeded via intramolecular reaction between the thiol and bromomethyl groups.

A mild method for the replacement of a hydroxyl group by halogen. 1. Scope and chemoselectivity

α-Chloro-, bromo- and iodoenamines, which are readily prepared from the corresponding isobutyramides have been found to be excellent reagents for the transformation of a wide variety of alcohols or carboxylic acids into the corresponding halides. Yields are high and conditions are very mild thus allowing for the presence of sensitive functional groups. The reagents can be easily tuned allowing therefore the selective monohalogenation of polyhydroxylated molecules. The scope and chemoselectivity of the reactions have been studied and reaction mechanisms have been proposed.

3-methyl-3-penten-2-one preparation method

The invention relates to a preparation method of 3-methyl-3-amylene-2-ketone. The preparation method comprises the steps of mixing butanone and a solid acid catalyst at 0-80 DEG C, adding acetaldehyde, fully mixing, reacting continuously, separating and purifying after reaction to obtain the 3-methyl-3-amylene-2-ketone, wherein the solid acid catalyst is highly-acidic dry type sulfonic acid group based polystyrene with H or sulfonic acid group based perfluorination cation exchange resin. According to the method, the solid acid catalyst is adopted, compared with the traditional synthetic method that strong acid and strong base are used, the method can greatly reduce the follow-up separation difficulty and environment pollution degree, no equipment corrosion is caused, and the product yield and the purity are high, therefore, the preparation method of 3-methyl-3-amylene-2-ketone is green and environment-friendly; and besides, no assisted solvent is adopted, the follow-up separation difficulty is reduced, the energy consumption and the production cost are low, and the industrial reliability is strong.

Aluminum oxide-induced gas-phase ring-opening in methyl substituted gem-difluorocyclopropanes, leading to 2-fluorobuta-1,3-dienes and vinylacetylenes

A gas-phase pyrolysis of methyl-substituted gem-difluorocyclopropanes in a flow-tube reactor in the presence of Al2O3 at 185 - 250 °C gives 2-fluorobuta-1,3-dienes and vinylacetylenes.