26060-01-5Relevant academic research and scientific papers
One pot synthesis of some new N-allyl and N-benzyl quinazolinones and their anti-inflammatory activity
Sudula, Sudharshan Reddy,Jala, Ranjith,Siddoju, Kavitha,Ega, Jagadeesh Kumar
, (2021/06/28)
The simple and more reliable one-pot synthesis of some novel compounds of allyl/Benzyl quinazolinone (4aa-4bd) with good yields from readily available derivatives of anthranilic acid and benzoyl chloride was also reported. Interestingly, as compared to Di
Potential anti-proliferative agents from 1,4-benzoxazinone-quinazolin-4(3H)-one templates
Bollu, Rajitha,Banu, Saleha,Kasaboina, Suresh,Bantu, Rajashaker,Nagarapu, Lingaiah,Polepalli, Sowjanya,Jain, Nishant
, p. 5481 - 5484 (2017/11/03)
A novel synthetic protocol has been developed for the synthesis of 1,4-benzoxazinone-acetylphenylallyl quinazolin-4(3H)-one hybrids 7a–n by employing Pd-catalyzed C[sbnd]H arylation in presence of 5–10% phosphine ligand in good to excellent yields and evaluated for their anti-proliferative activity against three cancer cell lines such as A549 (lung), HeLa (cervical), MDA-MB-231 (breast). Compounds 7d, 7f, 7l and 7n exhibited promising anti-proliferative activity with GI50 values ranging from 0.37 to 2.73 μM respectively against A549, HeLa, and MDA-MB-231, while compound 7f showed significant activity against MDA-MB-231 with GI50 value 0.58 μM, 7j showed significant activity against A549 with GI50 value 0.32 μM and 7l showed significant activity against HeLa with GI50 value 0.37 μM. This is the first report on the synthesis and in vitro anti-proliferative evaluation of 1,4-benzoxazinone-acetylphenylallyl quinazolin-4(3H)-one hybrids.
Quinazolinones-Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents
Palem, Jyothsna Devi,Alugubelli, Gopi Reddy,Bantu, Rajashaker,Nagarapu, Lingaiah,Polepalli, Sowjanya,Jain, S. Nishanth,Bathini, Raju,Manga, Vijjulatha
, p. 3014 - 3018 (2016/06/13)
A new series of novel quinazolinones with allylphenyl quinoxaline hybrids 9a-n were efficiently synthesized in good yields by the reaction of 3-allyl-2-methylquinazolin-4(3H)-one (5a-n) with bromophenyl)quinoxaline (8) utilizing Pd catalyzed Heck-cross coupling and evaluated for anti-proliferative activity against four cancer cell lines such as HeLa (cervical), MIAPACA (pancreatic), MDA-MB-231 (breast) and IMR32 (neuroblastoma). Compounds 9a, 9e, 9g and 9h exhibited promising anti-proliferative activity with GI50 values ranging from 0.06 to 0.2 μM against four cell lines, while compounds 9e and 9k showed significant activity against HeLa and MIAPACA cell lines and compounds 9b, 9d, 9h and 9j showed selective potency against IMR32 and MDA-MB-231 cell lines. This is the first report on the synthesis and in vitro anti-proliferative evaluation of E-2-(4-substituted)-3-(3-(4-(quinoxalin-2-yl)phenyl)allyl)quinazolin-4(3H)-ones (9a-n). Docking results indicate a sign of good correlation between experimental activity and calculated binding affinity (dock score), suggesting that these compounds could act as promising DNA intercalates.
Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors
Sadig, Jessie E. R.,Foster, Radleigh,Willis, Michael C.,Wakenhut, Florian
, p. 9473 - 9486,14 (2012/12/12)
N-(o-Halophenyl)imidoyl chlorides and the corresponding imidates are easily prepared and can be utilized as complementary precursors for the synthesis of important heterocycles. The synthesis of N-substituted benzimidazoles was possible from the palladium
Pyrido[2,3-d]pyrimidine derivatives: Synthesis via the intermolecular aza-Wittig reaction/heterocyclization and the crystal structure
Okawa, Tomohiro,Toda, Mieko,Eguchi, Shoji,Kakehi, Akikazu
, p. 1467 - 1475 (2007/10/03)
Pyrido[2,3-d]pyrimidine derivatives 5 were synthesized by the intermolecular aza-Wittig reaction of 2- (triphenylphosphoranylidene)aminonicotinamides 3 derived from 2- aminonicotinic acid (1), with carboxylic acid chloride followed by heterocyclization vi
