26060-01-5

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-phenyl-3-(2-propenyl)-
• CAS NO: 26060-01-5
• Molecular Formula: C17H14N2O
• Molecular Weight: 262.311
• Mol File: 26060-01-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-phenyl-3-(2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-phenyl-3-(2-propenyl)-(26060-01-5)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-phenyl-3-(2-propenyl)-(26060-01-5)

Safety Data

• Hazardous Substances Data: 26060-01-5(Hazardous Substances Data)

Upstream product

• 707-07-3 orthobenzoic acid trimethyl ester 
• 615-36-1 2-bromoaniline 
• 1402939-08-5 (Z)-methyl N-2-bromophenylbenzimidate 
• 107-11-9 1-amino-2-propene 
• 98-88-4 benzoyl chloride 
• 118-92-3 anthranilic acid 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 106-95-6 allyl bromide 
• 121998-76-3 2-phenyl-2,3-dihydro-4(1H)-quinazolinone 
• 100-52-7 benzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 4943-82-2 N-allyl-2-aminobenzamide 
• 215734-48-8 allyl 2-(triphenylphosphoranylideneamino)aminobenzoic carboxamide 

Relevant articles and documents

One pot synthesis of some new N-allyl and N-benzyl quinazolinones and their anti-inflammatory activity

The simple and more reliable one-pot synthesis of some novel compounds of allyl/Benzyl quinazolinone (4aa-4bd) with good yields from readily available derivatives of anthranilic acid and benzoyl chloride was also reported. Interestingly, as compared to Di

Quinazolinones-Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents

A new series of novel quinazolinones with allylphenyl quinoxaline hybrids 9a-n were efficiently synthesized in good yields by the reaction of 3-allyl-2-methylquinazolin-4(3H)-one (5a-n) with bromophenyl)quinoxaline (8) utilizing Pd catalyzed Heck-cross coupling and evaluated for anti-proliferative activity against four cancer cell lines such as HeLa (cervical), MIAPACA (pancreatic), MDA-MB-231 (breast) and IMR32 (neuroblastoma). Compounds 9a, 9e, 9g and 9h exhibited promising anti-proliferative activity with GI50 values ranging from 0.06 to 0.2 μM against four cell lines, while compounds 9e and 9k showed significant activity against HeLa and MIAPACA cell lines and compounds 9b, 9d, 9h and 9j showed selective potency against IMR32 and MDA-MB-231 cell lines. This is the first report on the synthesis and in vitro anti-proliferative evaluation of E-2-(4-substituted)-3-(3-(4-(quinoxalin-2-yl)phenyl)allyl)quinazolin-4(3H)-ones (9a-n). Docking results indicate a sign of good correlation between experimental activity and calculated binding affinity (dock score), suggesting that these compounds could act as promising DNA intercalates.

Pyrido[2,3-d]pyrimidine derivatives: Synthesis via the intermolecular aza-Wittig reaction/heterocyclization and the crystal structure

Pyrido[2,3-d]pyrimidine derivatives 5 were synthesized by the intermolecular aza-Wittig reaction of 2- (triphenylphosphoranylidene)aminonicotinamides 3 derived from 2- aminonicotinic acid (1), with carboxylic acid chloride followed by heterocyclization vi