26060-03-7

Upstream product

• 107468-35-9 5-Methoxy-2-phenyl-3H-benzo[e][1,4]diazepine 
• 16347-95-8 4-methoxyquinazoline 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 7471-86-5 methyl benzimidate 
• 6484-25-9 4-chloro-2-phenylquinazoline 
• 2446-51-7 N-methoxybenzamide 
• 14442-09-2 5-phenyloxazol-2(5H)-one 
• 124-41-4 sodium methylate 
• 40288-69-5 N-(2-cyanophenyl)benzamide 

Downstream Products

• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 1022-44-2 4-amino-2-phenyl-quinazoline 

Relevant academic research and scientific papers

Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization

An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield

Quinazoline synthesis via Rh(III)-catalyzed intermolecular C-H functionalization of benzimidates with dioxazolones

An efficient double C-N bond formation sequence to prepare highly substituted quinazolines utilizing benzimidates and dioxazolones under the catalytic redox-neutral [Cp?RhCl2]2/AgBF4 system, where dioxazolones could work as an intern

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.

ACID ALKYLATING AGENT, METHOD FOR GENERATING ACID ALKYLATION PRODUCT, RESIN COMPOSITION AND POLYESTER FILM

PROBLEM TO BE SOLVED: To provide: an acid alkylating agent which causes less generation of irritant gas and suppresses generation of a gel component; a method for generating an acid alkylation product; a resin composition; and a polyester film. SOLUTION: There are provided: an acid alkylation agent represented by the following general formula (1) obtained by subjecting a compound having at least one acidic group selected from a carboxylic acid group, a sulfonic acid group, a phosphate group and a phenolic hydroxyl group to acid alkylation; a method for generating an acid alkylation product; a resin composition; and a polyester film. Q represents a group for bonding with a -C=N- site to form a 5 to 12- membered nitrogen-containing heterocycle; R11 to R13 each independently represents a hydrogen atom, an alkyl group or an aryl group; and R11 to R13 may be bonded each other to form a ring. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Overcoming the Limitations of C?H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis

Strongly coordinating nitrogen heterocycles, including pyrimidines, oxazolines, pyrazoles, and pyridines, were fully tolerated in cobalt-catalyzed C?H amidations by imidate assistance. Structurally complex quinazolines are thus accessible in a step-economic manner. Our findings also establish the relative powers of directing groups in cobalt(III)-catalyzed C?H functionalization for the first time.

Thermal ring contraction of 3H-1,4-benzo- diazepines into quinazolines

The thermolysis of the 5-methoxy-(11a-c) and 5-diethylamino-3H-1,4- benzodiazepines (14a-c) resulted in a ring transformation to give the 4- methoxy-(12a-c) and 4-diethylaminoquinazolines (15a-c), respectively. The mechanism of this ring contraction is also described.

RING OPENING OF 4-CHLOROQUINAZOLINE INTO 2-ARYLMETHYLENEAMINOBENZONITRILE BY GRIGNARD REACTION

The treatment of 4-chloroquinazoline (1) with arylmagnesium bromide (3) in tetrahydrofuran (THF) resulted in the formation of 2-arylmethyleneaminobenzonitrile (2).Continued reaction of ring opening of 1 and subsequent hydrolysis of the products (2) afforded the corresponding arenecarbaldehydes (4).

HAMMETT-TAFT CONSTANTS OF SUBSTITUTED 2- AND 4-QUINAZOLINYL GROUPS

From the chemical shifts of the meta- and para-carbon atoms of the phenyl group in phenylquinazolines the ?I and ?R0 constants of 2- and 4-quinazolinyl groups were determined.Correlation equations which enable us to calcul