26060-03-7

Upstream product

• 6484-25-9 4-chloro-2-phenylquinazoline 
• 124-41-4 sodium methylate 
• 2446-51-7 N-methoxybenzamide 
• 7471-86-5 methyl benzimidate 
• 14442-09-2 5-phenyloxazol-2(5H)-one 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 16347-95-8 4-methoxyquinazoline 
• 107468-35-9 5-Methoxy-2-phenyl-3H-benzo[e][1,4]diazepine 
• 40288-69-5 N-(2-cyanophenyl)benzamide 

Downstream Products

• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 1022-44-2 4-amino-2-phenyl-quinazoline 

Relevant academic research and scientific papers

Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization

An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield

ACID ALKYLATING AGENT, METHOD FOR GENERATING ACID ALKYLATION PRODUCT, RESIN COMPOSITION AND POLYESTER FILM

PROBLEM TO BE SOLVED: To provide: an acid alkylating agent which causes less generation of irritant gas and suppresses generation of a gel component; a method for generating an acid alkylation product; a resin composition; and a polyester film. SOLUTION: There are provided: an acid alkylation agent represented by the following general formula (1) obtained by subjecting a compound having at least one acidic group selected from a carboxylic acid group, a sulfonic acid group, a phosphate group and a phenolic hydroxyl group to acid alkylation; a method for generating an acid alkylation product; a resin composition; and a polyester film. Q represents a group for bonding with a -C=N- site to form a 5 to 12- membered nitrogen-containing heterocycle; R11 to R13 each independently represents a hydrogen atom, an alkyl group or an aryl group; and R11 to R13 may be bonded each other to form a ring. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Overcoming the Limitations of C?H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis

Strongly coordinating nitrogen heterocycles, including pyrimidines, oxazolines, pyrazoles, and pyridines, were fully tolerated in cobalt-catalyzed C?H amidations by imidate assistance. Structurally complex quinazolines are thus accessible in a step-economic manner. Our findings also establish the relative powers of directing groups in cobalt(III)-catalyzed C?H functionalization for the first time.

Quinazoline synthesis via Rh(III)-catalyzed intermolecular C-H functionalization of benzimidates with dioxazolones

An efficient double C-N bond formation sequence to prepare highly substituted quinazolines utilizing benzimidates and dioxazolones under the catalytic redox-neutral [Cp?RhCl2]2/AgBF4 system, where dioxazolones could work as an intern

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.

Thermal ring contraction of 3H-1,4-benzo- diazepines into quinazolines

The thermolysis of the 5-methoxy-(11a-c) and 5-diethylamino-3H-1,4- benzodiazepines (14a-c) resulted in a ring transformation to give the 4- methoxy-(12a-c) and 4-diethylaminoquinazolines (15a-c), respectively. The mechanism of this ring contraction is also described.

RING OPENING OF 4-CHLOROQUINAZOLINE INTO 2-ARYLMETHYLENEAMINOBENZONITRILE BY GRIGNARD REACTION

The treatment of 4-chloroquinazoline (1) with arylmagnesium bromide (3) in tetrahydrofuran (THF) resulted in the formation of 2-arylmethyleneaminobenzonitrile (2).Continued reaction of ring opening of 1 and subsequent hydrolysis of the products (2) afforded the corresponding arenecarbaldehydes (4).

HAMMETT-TAFT CONSTANTS OF SUBSTITUTED 2- AND 4-QUINAZOLINYL GROUPS

From the chemical shifts of the meta- and para-carbon atoms of the phenyl group in phenylquinazolines the ?I and ?R0 constants of 2- and 4-quinazolinyl groups were determined.Correlation equations which enable us to calcul