26060-03-7

Basic information

• Product Name: 4-methoxy-2-phenylquinazoline
• Synonyms: 4-methoxy-2-phenylquinazoline
• CAS NO: 26060-03-7
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.26858
• Mol File: 26060-03-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methoxy-2-phenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-2-phenylquinazoline(26060-03-7)
• EPA Substance Registry System: 4-methoxy-2-phenylquinazoline(26060-03-7)

Safety Data

• Hazardous Substances Data: 26060-03-7(Hazardous Substances Data)

Upstream product

• 107468-35-9 5-Methoxy-2-phenyl-3H-benzo[e][1,4]diazepine 
• 2446-51-7 N-methoxybenzamide 
• 7471-86-5 methyl benzimidate 
• 6484-25-9 4-chloro-2-phenylquinazoline 
• 14442-09-2 5-phenyloxazol-2(5H)-one 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 16347-95-8 4-methoxyquinazoline 
• 124-41-4 sodium methylate 
• 40288-69-5 N-(2-cyanophenyl)benzamide 

Downstream Products

• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 1022-44-2 4-amino-2-phenyl-quinazoline 

Relevant articles and documents

Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization

An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield

Overcoming the Limitations of C?H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis

Strongly coordinating nitrogen heterocycles, including pyrimidines, oxazolines, pyrazoles, and pyridines, were fully tolerated in cobalt-catalyzed C?H amidations by imidate assistance. Structurally complex quinazolines are thus accessible in a step-economic manner. Our findings also establish the relative powers of directing groups in cobalt(III)-catalyzed C?H functionalization for the first time.

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.