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Usage

Uses

Used in Scientific Research and Experimentation:
2',5'-Dichloroacetanilide is used as a chemical intermediate in the synthesis of various organic compounds for scientific research and experimentation. Its unique structure and properties make it a valuable component in the development of new chemical compounds and materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2',5'-dichloracetanilide is used as a precursor in the synthesis of certain pharmaceutical compounds. Its specific chemical properties allow it to be a key component in the development of new drugs and medications.
Used in Chemical Synthesis:
2',5'-Dichloroacetanilide is used as a reagent in chemical synthesis processes. Its ability to react with other compounds and form new chemical entities makes it a useful tool in the creation of various chemical products.
Used in Analytical Chemistry:
In analytical chemistry, 2',5'-dichloracetanilide can be used as a reference compound or standard for the calibration of analytical instruments. Its distinct chemical properties allow for accurate measurements and comparisons in various analytical techniques.
Used in Environmental Research:
2',5'-Dichloroacetanilide can be used in environmental research to study the effects of organochlorine compounds on ecosystems and human health. Its presence in the environment can provide insights into the behavior and impact of similar compounds.
Used in Material Science:
In material science, 2',5'-dichloracetanilide may be used in the development of new materials with specific properties. Its unique structure and reactivity can contribute to the creation of advanced materials for various applications.

Upstream product

• 95-82-9 2,5 dichloroaniline 
• 108-24-7 acetic anhydride 
• 29551-86-8 N-chloro-m-chloroacetanilide 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 588-07-8 3-Chloroacetanilide 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 3032-32-4 3,6-dichloroanthranilic acid 

Downstream Products

• 5392-82-5 2,5-dichlorophenylisocyanate 
• 19368-22-0 N-(2,5-dichloro-phenyl)-phthalamic acid 
• 62248-07-1 thioacetic acid-(2,5-dichloro-anilide) 
• 6627-34-5 2,5-dichloro-4-nitroaniline 
• 38411-18-6 acetic acid-(3,6-dichloro-2-nitro-anilide) 
• 38411-17-5 2,5-dchloro-4-nitroacetanilide 
• 15944-74-8 3,6-dichloro-2-nitro-aniline 
• 342043-37-2 3,5-dichloro-2-nitroacetanilide 
• 23627-24-9 N-(2,4,5-trichlorophenyl)acetamide 
• 99310-47-1 acetic acid-(2,3,4-trichloro-anilide) 
• 112160-75-5 acetic acid-(2,5,N-trichloro-anilide) 
• 131195-87-4 2,5-bis(phenylthio)acetanilide 
• 38382-45-5 5,8-Dichlor-1,2,3,4-tetraphenylnaphthalin 
• 13276-99-8 N⁴-Acetyl-2.5-dichlor-sulfanilylhydrazid 

Relevant academic research and scientific papers

Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic system in water

Developing and/or modifying fundamental chemical reactions using chemical industry-favorite heterogeneous recoverable catalytic systems in the water solvent is very important. In this paper, we developed convenient, green, and efficient approaches for the chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes in the presence of the recoverable heterogeneous carbon-supported palladium (Pd/C) catalytic system in water. The utilize of the simple, effective, and recoverable catalyst and also using of water as an entirely green solvent along with relatively short reaction times and good-to-excellent yields of the desired products are some of the noticeable features of the presented synthetic protocols. Graphic abstract: [Figure not available: see fulltext.].

Nickel(II)- And Silver(I)-Catalyzed C-H Bond Halogenation of Anilides and Carbamates

ortho -C-H bond halogenation of anilides and N -aryl carbamates using easily available N -halosuccinimides (NXS) as the active halogenation reagent in the presence of nickel or silver catalyst has been developed. This method provides a new approach to 2-haloanilides and carbamates, which may serve as starting materials for the synthesis of pharmaceutically and biologically active compounds.

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

Ni2B@Cu2O and Ni2B@CuCl2: two new simple and efficient nanocatalysts for?the green one-pot reductive acetylation of nitroarenes and direct N-acetylation of arylamines using solvent-free mechanochemical grinding

Abstract: Ni2B@Cu2O and Ni2B@CuCl2 are introduced as simple and efficient earth-abundant transition-metal-based nanocomposites for the?green one-pot reductive acetylation of aromatic nitro compounds and direct N-acetylation of arylamines using a solvent-free mechanochemical grinding technique. The designed Ni2B-based nanocomposites were characterized by Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM) with energy-dispersive X-ray (EDX) spectroscopy. Notable advantages of these methods include broad substrate scope, use of a solvent-free mechanochemical grinding technique, implementation of earth-abundant transition-metal-based nanocomposites as simple and practical catalysts, and short reaction time and high yield at ambient condition. The mentioned methods can also be successfully applied for the?synthesis of a broad range of other amides (especially substituted acetamides) using green chemistry protocols. Also, the recoverability and reusability of the mentioned new nanocomposites were investigated. Graphical abstract: [Figure not available: see fulltext.].

L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate (supported on silica gel) as a new and efficient catalyst for acylation of alcohols, phenols and amines under solvent-free conditions

In the present work, L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate, supported on silica gel was prepared and characterized by Mass spectroscopy, 1H NMR, 13CNMR, FT IR and elemental analysis (CHN) methods. This heterogenized catalyst can be used as an efficient catalyst for the acylation of alcohols, phenols, and amines with acetic anhydride under mild and solvent-free conditions. Simple work-up, stability of the catalyst, nontoxicity and good to high yields are the advantages of this work.

Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the?directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.