2628-88-8

Upstream product

• 6727-73-7 4-iodobutyronitrile 
• 28744-77-6 sodium diethyl-2-phenylmalonate 
• 223690-15-1 methyl 5-bromo-2-phenylpentanoate 
• 143-33-9 sodium cyanide 
• 83-13-6 diethyl 2-phenylmalonate 
• 5332-06-9 4-bromobutanenitrile 
• 1444-65-1 (RS)-2-phenylcyclohexanone 
• 109-94-4 formic acid ethyl ester 
• 97024-67-4 5-Formyl-5-phenyl-valeriansaeure-methylester 
• 15232-96-9 3-phenyl-1-cyclohexene 
• 201230-82-2 carbon monoxide 
• 52755-38-1 1-phenyl-2-buten-1-ol 
• 98-88-4 benzoyl chloride 
• 4553-07-5 ethyl phenylcyanoacetate 

Downstream Products

• 1924-30-7 diethyl 2-phenylhexanedioate 
• 17540-20-4 (S)-2-phenyl-adipic acid 
• 61604-86-2 (R)-2-phenyl-adipic acid 
• 312312-81-5 2-Amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4(5H)-one 
• 312312-85-9 7-phenyl-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4-(3H,5H)-dione 

Relevant academic research and scientific papers

Direct and Selective Synthesis of Adipic and Other Dicarboxylic Acids by Palladium-Catalyzed Carbonylation of Allylic Alcohols

A general and direct synthesis of dicarboxylic acids including industrially important adipic acid by palladium-catalyzed dicarbonylation of allylic alcohol is reported. Specifically, the combination of PdCl2 and a bisphosphine ligand (HeMaRaphos) promotes two different carbonylation reactions with high activity and excellent selectivity.

PRODUCTION OF ADIPIC ACID AND DERIVATIVES THEREOF

Production of adipic acid and derivatives thereof The invention relates to a catalytic process for the production of a compound of formula (I) from a compound of formula (II)

Synthesis of annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) using 1,3-oxazine-2,4(3H)-diones as key intermediates

Condensation of ethyl 3-phenyl-2-oxocyclopentanecarboxylate 5 with 2-(S-methylthio)isourea followed by hydrolysis with HC1 gave 6,7-dihydro-7-phenylcyclopenta[e][1,3]oxazine-2,4(3H,5H)-dione (10a). 7,8-Dihydro-8-phenyl-6H-cyclohexa[e][1,3]oxazine-2,4(3H,5H)-dione (10b) was synthesised by reacting 2-phenylcyclohexanone (9b) with N-(chlorocarbonyl) isocyanate. The oxazines 10a,b were reacted with ammonia to obtain the corresponding uracil derivatives 12a,b which after silylation were alkylated with diethoxymethane using trimethylsilyl triflate (TMS-triflate) as the catalyst or alkylated with chloromethyl ethyl ether to give annelated MKC-442 analogues 2,3 which are locked in a conformation close to the one of MKC-442. In spite of this, only moderate activities were found against HIV-1 for the annelated analogues of MKC-442. The Royal Society of Chemistry 2000.