6727-73-7Relevant articles and documents
NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVES AND METHOD FOR PREPARING THE SAME
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Paragraph 0431; 0432; 0433, (2014/09/16)
The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).
A new sequential intramolecular cyclization based on the boekelheide rearrangement
Massaro, Assunta,Mordini, Alessandro,Mingardi, Anna,Klein, Jens,Andreotti, Daniele
supporting information; experimental part, p. 271 - 279 (2011/02/28)
Pyrrolidines and piperidines were synthesized from (aminoalkyl)pyridine N-oxides with a general and quite efficient method developed by using di-tert-butylsilyl bis(trifluoromethanesulfonate) as a new promoter for a Boekelheide-type reaction. The use of a
Zn-promoted regioselective and sequence-selective one-pot joining reaction of three components: Alkyl iodides, α,β-unsaturated esters (or nitriles), and acylating agents
Yamamoto, Yoshimasa,Nakano, Seiji,Maekawa, Hirofumi,Nishiguchi, Ikuzo
, p. 799 - 802 (2007/10/03)
One-pot treatment of alkyl iodides, α,β-unsaturated esters (or nitriles), and acylating agents such as nitriles or acid anhydrides in the presence of Zn metal at room temperature in the same reaction system brought about a regioselective and sequence-selective three-component joining reaction involving first C-alkylation at the β-position and second C-acylation at the α-position of α,β-unsaturated esters (or nitriles) to afford the corresponding α,α-dialkylketoesters (or α,α-dialkylketonitriles) in moderate to good yields.
