26307-01-7

Usage

Uses

Used in Pharmaceutical Industry:
N,N-dichlorocyclohexanamine is used as a reactive intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the production of drugs with specific therapeutic properties.
Used in Agricultural Chemical Industry:
In the agricultural chemical industry, N,N-dichlorocyclohexanamine is utilized as a precursor in the synthesis of various agrochemicals, such as pesticides and herbicides. Its reactivity and versatility make it a valuable component in the development of effective and targeted agricultural products.
Used in Organic Compound Synthesis:
N,N-dichlorocyclohexanamine is employed as a versatile building block in the synthesis of a wide range of organic compounds. Its ability to form various chemical bonds and participate in different reaction pathways makes it a valuable asset in the creation of complex organic molecules for various applications.

Upstream product

• 108-91-8 cyclohexylamine 
• 4998-76-9 cyclohexylamine hydrochloride 

Downstream Products

• 6681-70-5 cyclohexyl-N-chloroketimine 
• 74386-79-1 N-cyclohexylnitramine 
• 68277-74-7 N,N-Dibromocyclohexylamin 
• 52123-66-7 N-Phenyl-N'-cyclohexyldiimide N-oxide 
• 110-83-8 cyclohexene 
• 185-79-5 3,3-pentamethylenediaziridine 

Relevant academic research and scientific papers

Organic chloramine analysis and free chlorine quantification by electrospray and atmospheric pressure chemical ionization tandem mass spectrometry

Atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI), together with tandem mass spectrometry (MSn), are used to study the mechanism of chlorination of amines and to develop a method for qualitative and quantitative determination of organic chloramines. Cyclohexylamine and 1,4-butanediamine (putrescine) are used as model compounds to investigate the mechanisms of the reactions between primary aliphatic amines and hypochlorous acid (aqueous Cl2). The chlorination products are identified and characterized by collision-induced dissociation (CID) and H/D exchange. Chlorination occurs by eledtrophilic addition of Cl+ and may be followed by HCl elimination, hydrolysis, or, in the case of diamines, amine elimination by intramolecular nucleophilic substitution. The relative rates of chlorination at amine and chloramine nitrogens are a function of pH and depend on the basicity of the amine. A novel method for active chlorine quantification using ESI or APCI mass spectrometry is suggested on the basis of the extent of chlorination of a sacrifical amine standard. This measurement has a limit of detection for N-chlorocyclohexylamine in the range of 0.1-10 μM, a linear dynamic range of 102-103, and an accuracy of ±10%, as determined for wastewater samples.

The N-chlorination of primary amines using FeCl3 and m-CPBA

A simple and effective method for the synthesis of N,Ndichloroamines from primary amines was conducted successfully with m-CPBA as oxidant and FeCl 3 as chlorine source at 0 °C. Moreover, N,N-dichloroamines could be converted into nitriles or N-chloroimines in good yields.

AGENTS FOR TREATING NEURODEGENERATIVE DISORDERS

The present invention relates to compounds of formula I, use of these compounds to treat mental and neurological disorders, especially depressions and psychoses of different etiology.. The compounds provided for the treatment of mental and neurological disorders are presented by a general formula I: wherein R, R', Y are as defined in specification or pharmaceutically acceptable salts thereof, solvates thereof such as hydrates, and pharmaceutical compositions containing such compounds.

An insight of the reactions of amines with trichloroisocyanuric acid

The reaction between amines or α-aminoacids with trichloroisocyanuric acid is studied under various conditions: N,N-dichloroamines, nitriles and ketones can be obtained from primary amines, while free aminoacids undergo oxidative decarboxylation to the corresponding nitrile of one less carbon atom.

Pyrolytic Eliminations from N,N-Dichloro Derivatives of Primary, Secondary, and Tertiary Alkyl Primary Amines

N,N-Dichloro derivatives of primary, secondary, and tertiary alkyl primary amines are easily converted to elimination products by neat or solution pyrolysis during GLC at 190-280 deg C.Good to excellent yields result.In general, the type of product formed depends on the alkyl group: with primary alkyl, the products are alkenes and nitriles; with secondary, alkenes and chloroimines result; and with tertiary types, alkenes are formed.Mechanistic aspects are treated.