2657-87-6Relevant articles and documents
Method for preparing 3, 4'-diaminodiphenyl ether
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Paragraph 0026-0032, (2020/05/14)
The invention discloses a method for preparing 3, 4'-diaminodiphenyl ether, which mainly comprises the following steps: adding m-aminophenol, an acid-binding agent and a solvent into a condensation reaction kettle, stirring, heating under the protection of inert gas, keeping the temperature at 100-120 DEG C, dropwisely adding p-nitrochlorobenzene, keeping the temperature for 2-4 hours after 5-7 hours, and continuing the reaction; after the reaction is finished, filtering to remove inorganic salt, transferring a filtrate into a hydrogenation kettle, adding a noble metal catalyst and a cocatalyst, performing nitrogen replacement, maintaining the temperature at 60-80 DEG C, and introducing hydrogen for catalytic hydrogenation under the hydrogen pressure of not more than 0.5 MPa; after the reaction is finished, filtering out the catalyst, distilling the filtrate, removing the solvent, rectifying, collecting 206-210 DEG C (2-3 mmHg) fraction which is white 3, 4'-diaminodiphenyl ether, and packaging under the protection of nitrogen. The method is short in process step, low in energy consumption and low in production cost, the content of the obtained 3, 4'-diaminodiphenyl ether is largerthan 99.5%, and the total molar yield is larger than 93%.
Orthogonal Cu- and Pd-based catalyst systems for the O- and N-arylation of aminophenols
Maiti, Debabrata,Buchwald, Stephen L.
supporting information; experimental part, p. 17423 - 17429 (2010/03/25)
O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods employing picolinic acid or CyDMEDA, trans-N,N′-dimethyl-1,2- cyclohexanediamine, respectively, as the ligand. The selective formation of N-arylated products of 3- and 4-aminophenols can be obtained with BrettPhos precatalyst, a biarylmonophosphine-based palladium catalyst. 2-Aminophenol can be selectively N-arylated with CuI, although no system for the selective O-arylation could be found. Coupling partners with diverse electronic properties and a variety of functional groups can be selectively transformed under these conditions.
Thermoplastic resin composition and a method of molding the same
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, (2008/06/13)
This invention provides a thermoplastic resin composition comprising a thermoplastic resin and 0.1 to 100 parts by weight, per 100 parts by weight of the thermoplastic resin, of an imide compound prepared, e.g., by dehydration condensation of 1,2,3,4-butanetetracarboxylic acid or a monoanhydride or a dianhydride thereof with a primary amine, and a method of molding the resin composition.